Chemical constituents on the aerial parts of Artemisia selengensis and their IL-6 inhibitory activity

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• 作者：A Ryun Kim ; Hae Ju Ko ; Md Anisuzzaman Chowdhury…
• 关键词：Artemisia selengensis Turcz. ; Compositae ; 1-3-propanediol ; 2-amino ; 1-(1 ; 3 ; benzodioxol ; 5 ; yl) ; IL ; 6 inhibitory activity
• 刊名：Archives of Pharmacal Research
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：38
• 期：6
• 页码：1059-1065
• 全文大小：557 KB
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• 作者单位：A Ryun Kim (1)
  Hae Ju Ko (1)
  Md Anisuzzaman Chowdhury (1)
  Young-Su Chang (1)
  Eun-Rhan Woo (1)
  
  1. BK 21 Plus Project Team, College of Pharmacy, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju, 501-759, South Korea
  
• 刊物主题：Pharmacy; Pharmacology/Toxicology;
• 出版者：Springer Netherlands
• ISSN：1976-3786

文摘

Ten compounds, 1-3-propanediol,2-amino-1-(1,3-benzodioxol-5-yl) (1), artanomaloide (2), canin (3), eupatilin (4), quercetin-3-O-β-d-glucoside-7-O-α-l-rhamnoside (5), 1,3-di-O-caffeoylquinic acid (6), isoquercitrin (7), pinoresinol-4-O-β-d-glucoside (8), scopolin (9), and isofraxidin-7-O-β-d-glucopyranoside (10) were isolated from the aerial parts of A. selengensis. The structures of compounds (1-strong class="EmphasisTypeBold">10) were identified based on 1D and 2D NMR, including 1H-sup>1H COSY, HSQC, HMBC and NOESY spectroscopic analyses. Among them, compound 1 was isolated from this plant for the first time as a naturally occurring compound. The inhibitory activity of these isolated compounds against interleukin-6 (IL-6) production in TNF-α stimulated MG-63 cells was also examined.