Functional connectivity during cognitive control in children with autism spectrum disorder: an independent component analysis

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• 作者：S. Ambrosino (1)
  D. J. Bos (1)
  T. R. van Raalten (1)
  N. A. Kobussen (1)
  J. van Belle (1)
  B. Oranje (1)
  S. Durston (1)
  
• 关键词：ASD ; Functional connectivity ; ICA ; Cognitive control ; Rigid behavior
• 刊名：Journal of Neural Transmission
• 出版年：2014
• 出版时间：September 2014
• 年：2014
• 卷：121
• 期：9
• 页码：1145-1155
• 全文大小：2,953 KB
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• 作者单位：S. Ambrosino (1)
  D. J. Bos (1)
  T. R. van Raalten (1)
  N. A. Kobussen (1)
  J. van Belle (1)
  B. Oranje (1)
  S. Durston (1)
  
  1. NICHE Lab, Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, HP A.01.126, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
  
• ISSN：1435-1463

文摘

Restrictive and repetitive behavior in autism may be related to deficits in cognitive control. Here, we aimed to assess functional connectivity during a cognitive control task and compare brain network activity and connectivity in children with autism spectrum disorders (ASD) and typically developing children using a multivariate data-driven approach. 19 high-functioning boys with ASD and 19 age-matched typically developing boys were included in this study. Functional magnetic resonance imaging was performed at 3T during the performance of a cognitive control task (go/no-go paradigm). Functional networks were identified using independent component analysis. Network activity and connectivity was compared between groups and correlated with clinical measures of rigid behavior using multivariate analysis of covariance. We found no differences between the groups in task performance or in network activity. Power analysis indicated that, if this were a real difference, it would require nearly 800 subjects to show group differences in network activity using this paradigm. Neither were there correlations between network activity and rigid behavior. Our data do not provide support for the presence of deficits in cognitive control in children with ASD, or the functional networks supporting this ability.