Functional-structural degeneration in dorsal and ventral attention systems for Alzheimer’s disease, amnestic mild cognitive impairment

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• 作者：Shaowen Qian ; Zhaoyan Zhang ; Bo Li ; Gang Sun
• 关键词：Dorsal attention network ; Ventral attention network ; Gray matter loss ; Functional ; structural coupling
• 刊名：Brain Imaging and Behavior
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：9
• 期：4
• 页码：790-800
• 全文大小：1,332 KB
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• 作者单位：Shaowen Qian (1)
  Zhaoyan Zhang (1)
  Bo Li (1)
  Gang Sun (1)
  
  1. Department of Medical Imaging, Jinan Military General Hospital, Shandong, People’s Republic of China
  
• 刊物主题：Neurosciences; Neuroradiology; Neuropsychology; Psychiatry;
• 出版者：Springer US
• ISSN：1931-7565

文摘

Growing evidence of attention related failures in patients with amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD) has already been proposed by previous studies. However, previous studies lacked of systematic investigation on the functional and structural substrates for attention function for patients with AD and aMCI. In this work, we investigated the functional connectivity and gray matter density in dorsal and ventral attention networks (DAN, VAN) of normal participants (n--5) and patients with aMCI (n--2) and AD (n--6) by applying group independent component analysis (ICA) and voxel-based morphometry (VBM) analysis. Using ICA, we extracted the functional patterns of DAN and VAN which are respectively responsible for the “top-down-attention process and “bottom-up-process. One-way analysis of variance (ANOVA) revealed significant group-differed functional connectivity in bilateral frontal eye fields (FEF) area and intraparietal sulcus (IPS) area, as well as posterior cingulate cortex and precuneus in the dorsal system. With regard to the ventral system, group-effects were significantly focused in right orbital superior/middle frontal gyrus, right inferior parietal lobule, angular gyrus, and supramarginal gyrus around the temporal-parietal junction area. Post hoc cluster-level comparisons revealed totally impaired functional substrates for both attentional networks for patients with AD, whereas selectively impaired attention systems for patients with aMCI with impaired functional patent of DAN but preserved functional pattern of VAN. Correspondingly, VBM analysis revealed gray matter loss in right ventral and dorsal frontal cortex was in the AD group, whereas preserved gray matter density was in aMCI, even a little extent of expansion of gray matter density in several participants. Using multivariate regression analysis we found discrepant couplings of functional-structural degenerations between both patient groups. Specifically, positive coupling of structural-functional degeneration was found in right dorsal and ventral frontal cortex in the AD group, whereas inverse coupling in dorsal frontal cortex was found in the aMCI group. These findings suggested discrepant functional-structural degenerations in both attention systems between both patient groups, widening avenues to better understanding the attentional deficits in patients with aMCI and AD. Keywords Dorsal attention network Ventral attention network Gray matter loss Functional-structural coupling