A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone

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• 作者：Lakshmi Swarna Mukhi Pidugu ; J.C. Emmanuel Mbimba ; Muqeet Ahmad…
• 关键词：NQO1 ; Dimeric naphthoquinone ; Oxidative stress ; Anti ; cancer agents
• 刊名：BMC Structural Biology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：16
• 期：1
• 全文大小：3,180 KB
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• 作者单位：Lakshmi Swarna Mukhi Pidugu (1) (2) (3)
  J.C. Emmanuel Mbimba (3)
  Muqeet Ahmad (3)
  Edwin Pozharski (1) (2) (3)
  Edward A. Sausville (2)
  Ashkan Emadi (2)
  Eric A. Toth (1) (2) (3)
  
  1. Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA
  2. Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, 21201, USA
  3. Institute for Bioscience and Biotechnology Research, and Center for Biomolecular Therapeutics, 9600 Gudelsky Drive, Rockville, MD, 20850, USA
  
• 刊物主题：Biochemistry, general; Protein Science; Crystallography; Mass Spectrometry; Spectroscopy/Spectrometry;
• 出版者：BioMed Central
• ISSN：1472-6807

文摘

Background Multimeric naphthoquinones are redox-active compounds that exhibit antineoplastic, antiprotozoal, and antiviral activities. Due to their multimodal effect on perturbation of cellular oxidative state, these compounds hold great potential as therapeutic agents against highly proliferative neoplastic cells. In our previous work, we developed a series of novel dimeric naphthoquinones and showed that they were selectively cytotoxic to human acute myeloid leukemia (AML), breast and prostate cancer cell lines. We subsequently identified the oxidoreductase NAD(P)H dehydrogenase, quinone 1 (NQO1) as the major target of dimeric naphthoquinones and proposed a mechanism of action that entailed induction of a futile redox cycling.