Mechanical endovascular thrombectomy for acute ischemic stroke: a retrospective multicenter study in Belgium

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• 作者：Niels Fockaert ; Marieke Coninckx ; Sam Heye ; Luc Defreyne…
• 关键词：Endovascular ; Thrombectomy ; Ischemic stroke ; Reperfusion ; Outcome
• 刊名：Acta Neurologica Belgica
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：116
• 期：1
• 页码：7-14
• 全文大小：711 KB
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• 作者单位：Niels Fockaert (1)
  Marieke Coninckx (2)
  Sam Heye (3)
  Luc Defreyne (4)
  Denis Brisbois (5)
  Pierre Goffette (6)
  Jan Gralla (7)
  Pasquale Mordasini (7)
  Andre Peeters (8)
  Philippe Desfontaines (9)
  Dimitri Hemelsoet (2)
  Vincent Thijs (1) (10) (11)
  Robin Lemmens (1) (10) (11)
  
  1. Department of Neurology, University Hospitals Leuven, 3000, Leuven, Belgium
  2. Department of Neurology, University Hospitals Gent, 9000, Ghent, Belgium
  3. Department of Radiology, University Hospitals Leuven, 3000, Leuven, Belgium
  4. Department of Vascular and Interventional Radiology, University Hospitals Gent, 9000, Ghent, Belgium
  5. Department of Interventional Neuroradiology, Centre Hospitalier Chrétien, 4000, Liège, Belgium
  6. Department of Neuroradiology, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium
  7. Department of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Bern, Switzerland
  8. Department of Neurology, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, 1200, Brussels, Belgium
  9. Department of Neurology, Centre Hospitalier Chrétien, 4000, Liège, Belgium
  10. Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven, University of Leuven, 3000, Leuven, Belgium
  11. VIB, Vesalius Research Center, Laboratory of Neurobiology, 3000, Leuven, Belgium
  
• 刊物主题：Neurosciences; Neurology; Neuroradiology; Medicine/Public Health, general;
• 出版者：Springer Milan
• ISSN：2240-2993

文摘

Clinical trials have shown a beneficial effect of mechanical thrombectomy in acute ischemic stroke patients treated within six up to even 12 h after symptom onset. This treatment was already performed in selected hospitals in Belgium before completion of the randomized controlled trials. Outcome data on these procedures in Belgium have not been published. We performed a retrospective multicenter study of all patients with acute ischemic stroke treated with mechanical endovascular therapy in four hospitals in Belgium. Clinical outcomes, as measured by the modified Rankin Scale (mRS), site of arterial occlusion, reperfusion and the association between these variables were studied. The study included 80 patients: 65 patients with an occlusion in the anterior circulation and 15 with an occlusion in the posterior circulation. Good functional outcome (GFO) rates, defined as mRS 0–2 at 90 days, were 42 % in all patients, 44 % in anterior circulation stroke and 34 % in posterior circulation stroke. Reperfusion was achieved in 78 % of patients; more (100 %) in patients with posterior compared to patients with anterior circulation stroke (72 %; p = 0.02). The rate of GFO was greater in patients with reperfusion versus patients in whom reperfusion was not achieved (adjusted OR 8.2, 95 % CI 2.0–34.2). Symptomatic intracerebral hemorrhage was documented in 5 % of all patients. Endovascular treatment with mechanical devices for acute ischemic stroke in Belgium results in GFO and reperfusion rates similar to recently published results in the endovascular-treated arms of randomized clinical trials. Rates of symptomatic intracranial hemorrhage are low and comparable to other cohort studies and clinical trials.