Fetale und perinatale Programmierung der Nierenfunktion

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• 作者：Prof. Dr. J. D枚tsch (1)
  
• 关键词：Intrauterine Wachstumsrestriktion ; Intrauterines Milieu ; Glomerul盲re Filtrationsrate ; Schwangerschaft ; Geburtsgewicht ; Intrauterine growth retardation ; Intrauterine environment ; Glomerular filtration rate ; Pregnancy ; Birth weight
• 刊名：Gyn?kologische Endokrinologie
• 出版年：2014
• 出版时间：May 2014
• 年：2014
• 卷：12
• 期：2
• 页码：87-92
• 全文大小：
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• 作者单位：Prof. Dr. J. D枚tsch (1)
  
  1. Klinik und Poliklinik f眉r Kinder- und Jugendmedizin, Uniklinik K枚ln, Kerpener Str. 62, 50937, K枚ln, Deutschland
  
• ISSN：1610-2908

文摘

Impact Low birth weight is associated with reduced renal function which is sometimes already present in childhood. Among the diseases that are encountered more frequently or are more severe are glomerular diseases, hypertension, and chronic kidney disease. Causes A potential cause of this phenomenon is fetal programming which is defined as a permanent alteration of biological function by a temporary intrauterine event. However, low birth weight is not the only factor influencing renal function via fetal programming. Other factors include maternal diabetes, maternal smoking, high salt intake, and the administration of glucocorticoids during pregnancy. Mechanisms Possible mechanisms that may be involved are impaired nephrogenesis, which is represented by a diminished number of nephrons and other renal and extrarenal mechanisms. Human and animal data suggest that the consequences of fetal programming are influenced by the postnatal environment to a large extent. One of those postnatal modifiers appears to be nutrition in infancy and early childhood.