Insulin stimulates SGLT2-mediated tubular glucose absorption via oxidative stress generation

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• 作者：Nobutaka Nakamura ; Takanori Matsui ; Yuji Ishibashi…
• 关键词：SGLT2 ; Oxidative stress ; Insulin ; Diabetic nephropathy ; AGEs
• 刊名：Diabetology and Metabolic Syndrome
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：7
• 期：1
• 全文大小：676 KB
• 刊物主题：Diabetes; Metabolic Diseases; Endocrinology;
• 出版者：BioMed Central
• ISSN：1758-5996

文摘

Background Ninety percent of glucose filtered by the glomerulus is reabsorbed by a sodium-glucose cotransporter 2 (SGLT2), which is expressed mainly on the apical membrane of renal proximal tubules. Since SGLT-2-mediated glucose reabsorption is enhanced under diabetic conditions, selective inhibition of SGLT2 has been proposed as a potential therapeutic target for the treatment of patients with diabetes. However, it remains unclear which diabetes-associated factors are involved in overexpression of SGLT2.