Intrathecal drug delivery for chronic pain management-scope, limitations and future

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• 作者：M. Czernicki (1)
  G. Sinovich (2)
  I. Mihaylov (3)
  B. Nejad (2)
  S. Kunnumpurath (2)
  G. Kodumudi (5)
  N. Vadivelu (4)
  
  1. Department of Pain Medicine ; Nottingham University Hospitals NHS Trust ; Nottingham ; UK
  2. Department of Pain Medicine ; Epsom and St Helier University Hospitals NHS Trust ; Epsom ; UK
  3. Department of Pain Medicine ; Royal National Orthopaedic Hospital NHS Trust ; Stanmore ; UK
  5. School of Liberal Arts and Science ; University of Connecticut ; Storrs ; CT ; USA
  4. Department of Anesthesiology ; Yale University School of Medicine ; New Haven ; CT ; USA
  
• 关键词：Chronic non ; malignant pain ; Cancer pain ; Intrathecal drug delivery system
• 刊名：Journal of Clinical Monitoring and Computing
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：29
• 期：2
• 页码：241-249
• 全文大小：201 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Anesthesiology
  Intensive and Critical Care Medicine
  Statistics for Life Sciences, Medicine and Health Sciences
  
• 出版者：Springer Netherlands
• ISSN：1573-2614

文摘

Intrathecal drug delivery system (IDDS) is a targeted therapy system for treating pain and muscle spasm. IDDS is recommended for the treatment of chronic pain which does not respond to optimal medical management. The aim of this review article is to give an up to date and concise account of the use of IDDS. It will explore the main indications, pre-implantation trials and different implantation techniques, the licensing of drugs for intrathecal use and the adverse effects and benefits of this therapy. IDDS is an invasive technique, which can result in severe morbidity and mortality. The up to date knowledge gained from this article along with the recommendations for improving safety in patients receiving IDDS, makes it a valuable resource for healthcare practitioners. Continued research, including outcome studies of this therapy continues to be necessary.