Genetic polymorphisms and their association with central retinal vein occlusion combined with cilioretinal artery occlusion

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• 作者：Meriem Mrad ; Chaima Wathek ; Aicha Sayeh ; Sami Layouni…
• 关键词：Central retinal vein occlusion ; Cilioretinal artery occlusion ; Genetic polymorphisms
• 刊名：Comparative Clinical Pathology
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：24
• 期：3
• 页码：537-540
• 全文大小：108 KB
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• 作者单位：Meriem Mrad (1) (2)
  Chaima Wathek (3) (4)
  Aicha Sayeh (1) (2)
  Sami Layouni (1) (5)
  Riadh Rannen (3) (4)
  Salem Gabsi (3) (4)
  Nasreddine Gritli (1) (5)
  Najiba Fekih-Mrissa (1) (6)
  
  1. Service d鈥橦茅matologie, Laboratoire de Biologie Mol茅culaire, H么pital Militaire Principal d鈥橧nstruction de Tunis, 1008, Montfleury, Tunisie
  2. Facult茅 des Science de Tunis, Universit茅 Tunis el Manar, El Manar, Tunisie
  3. Service d鈥橭phtalmologie, H么pital Militaire Principal d鈥橧nstruction de Tunis, 1008, Montfleury, Tunisie
  4. Facult茅 de M茅decine de Tunis, Universit茅 Tunis el Manar, 1007, Tunis, Tunisie
  5. Facult茅 de Pharmacie, Universit茅 de Monastir, 5000, Monastir, Tunisie
  6. Acad茅mie Militaire Fondouk J茅did, 8012, Nabeul, Tunisie
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pathology
  Hematology
  Oncology
  
• 出版者：Springer London
• ISSN：1618-565X

文摘

Combined cilioretinal artery and retinal vein occlusions are infrequently documented retinal vascular disorders. The role of genetic polymorphisms has been investigated. A 45-year-old woman presented with decreased visual acuity in her right eye. Fluorescein angiography demonstrated a cilioretinal artery occlusion associated with central retinal vein obstruction. Results of testing for the factor V Leiden were negative. However, the patient was heterozygous for the prothrombin G20210A mutation and the two polymorphisms (C667T and A1298C) of the methylenetetrahydrofolate reductase (MTHFR) gene. Specific genetic factors can be associated with retinal vascular occlusions.