Fructose only in pregnancy provokes hyperinsulinemia, hypoadiponectinemia, and impaired insulin signaling in adult male, but not female, progeny

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• 作者：Lourdes Rodríguez ; María I. Panadero ; Núria Roglans…
• 关键词：Fructose ; Pregnancy ; Fetal programming ; Metabolic syndrome
• 刊名：European Journal of Nutrition
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：55
• 期：2
• 页码：665-674
• 全文大小：676 KB
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• 作者单位：Lourdes Rodríguez (1)
  María I. Panadero (1)
  Núria Roglans (2)
  Paola Otero (1)
  Silvia Rodrigo (1)
  Juan J. Álvarez-Millán (3)
  Juan C. Laguna (2)
  Carlos Bocos (1)
  
  1. Facultad de Farmacia, Universidad San Pablo-CEU, Urbanización Montepríncipe, 28668, Boadilla del Monte, Madrid, Spain
  2. Facultad de Farmacia, Universidad de Barcelona, CIBERobn, Barcelona, Spain
  3. CQS Lab, Madrid, Spain
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nutrition
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1436-6215

文摘

Purpose Fructose intake from added sugars correlates with the epidemic rise in metabolic syndrome and cardiovascular diseases. However, consumption of beverages containing fructose is allowed during gestation. Recently, we found that an intake of fructose (10 % wt/vol) throughout gestation produces impaired fetal leptin signaling and hepatic steatosis. Therefore, we have investigated whether fructose intake during pregnancy produces subsequent changes in the progeny, when adult.