| |
Enhanced fatty acid uptake in visceral adipose tissue is not reversed by weight loss in obese individuals with the metabolic syndrome
- 作者:Marco Bucci (1)
Anna C. Karmi (1) Patricia Iozzo (1) (2) Barbara A. Fielding (3) Antti Viljanen (4) Robert M. Badeau (1) Ronald Borra (1) (5) Virva Saunavaara (1) Tam Pham (1) Jarna C. Hannukainen (1) Kari Kalliokoski (1) Merja Haaparanta-Solin (1) Tapio Viljanen (1) Riitta Parkkola (1) (6) Keith N. Frayn (3) Pirjo Nuutila (1) (7)
- 关键词:[U ; 13C] ; palmitate ; [18F] ; Fluoro ; 6 ; thia ; heptadecanoic acid ; Indirect calorimetry ; NEFA ; Obesity ; Positron emission tomography ; Subcutaneous adipose tissue ; Very low calorie diet ; Visceral adipose tissue ; Weight loss
- 刊名:Diabetologia
- 出版年:2015
- 出版时间:January 2015
- 年:2015
- 卷:58
- 期:1
- 页码:158-164
- 全文大小:253 KB
- 参考文献:1. Ibrahim MM (2010) Subcutaneous and visceral adipose tissue: structural and functional differences. Obes Rev 11:11-8 CrossRef
2. Manolopoulos KN, Karpe F, Frayn KN (2010) Gluteofemoral body fat as a determinant of metabolic health. Int J Obes (Lond) 34:949-59 CrossRef 3. Snijder MB, Visser M, Dekker JM et al (2005) Low subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat. Health ABC Study Diabetol 48:301-08 4. Okura T, Nakata Y, Yamabuki K, Tanaka K (2004) Regional body composition changes exhibit opposing effects on coronary heart disease risk factors. Arterioscler Thromb Vasc Biol 24:923-29 CrossRef 5. Westphal SA (2008) Obesity, abdominal obesity, and insulin resistance. Clin Cornerstone 9:23-9 CrossRef 6. Jakobsen MU, Berentzen T, Sorensen TI, Overvad K (2007) Abdominal obesity and fatty liver. Epidemiol Rev 29:77-7 CrossRef 7. Sinha R, Dufour S, Petersen KF et al (2002) Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity. Diabetes 51:1022-027 CrossRef 8. Hannukainen JC, Kalliokoski KK, Borra RJ et al (2010) Higher free fatty acid uptake in visceral than in abdominal subcutaneous fat tissue in men. Obesity (Silver Spring) 18:261-65 CrossRef 9. Bucci M, Borra R, Nagren K et al (2011) Human obesity is characterized by defective fat storage and enhanced muscle fatty acid oxidation, and trimetazidine gradually counteracts these abnormalities. Am J Physiol Endocrinol Metab 301:E105–E112 CrossRef 10. Labbe SM, Grenier-Larouche T, Noll C et al (2012) Increased myocardial uptake of dietary fatty acids linked to cardiac dysfunction in glucose-intolerant humans. Diabetes 61:2701-710 CrossRef 11. Labbe SM, Grenier-Larouche T, Croteau E et al (2011) Organ-specific dietary fatty acid uptake in humans using positron emission tomography coupled to computed tomography. Am J Physiol Endocrinol Metab 300:E445–E453 CrossRef 12. Votruba SB, Mattison RS, Dumesic DA, Koutsari C, Jensen MD (2007) Meal fatty acid uptake in visceral fat in women. Diabetes 56:2589-597 CrossRef 13. Shadid S, Koutsari C, Jensen MD (2007) Direct free fatty acid uptake into human adipocytes in vivo: relation to body fat distribution. Diabetes 56:1369-375 CrossRef 14. Chaston TB, Dixon JB (2008) Factors associated with percent change in visceral versus subcutaneous abdominal fat during weight loss: findings from a systematic review. Int J Obes (Lond) 32:619-28 CrossRef 15. International Diabetes Federation (2006) The IDF consensus worldwide definition of the metabolic syndrome. http://www.idf.org/metabolic-syndrome 16. van Loon LJ, Manders RJ, Koopman R et al (2005) Inhibition of adipose tissue lipolysis increases intramuscular lipid use in type 2 diabetic patients. Diabetologia 48:2097-107 CrossRef 17. World Health Organization (2006) Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia. http://whq - 作者单位:Marco Bucci (1)
Anna C. Karmi (1) Patricia Iozzo (1) (2) Barbara A. Fielding (3) Antti Viljanen (4) Robert M. Badeau (1) Ronald Borra (1) (5) Virva Saunavaara (1) Tam Pham (1) Jarna C. Hannukainen (1) Kari Kalliokoski (1) Merja Haaparanta-Solin (1) Tapio Viljanen (1) Riitta Parkkola (1) (6) Keith N. Frayn (3) Pirjo Nuutila (1) (7)
1. Turku PET Centre, University of Turku and Turku University Hospital, P.O. Box 52, FI-20521, Turku, Finland 2. PET Centre, Institute of Clinical Physiology, National Research Council, Pisa, Italy 3. Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK 4. Department of Ophthalmology, University of Turku and Turku University Hospital, Turku, Finland 5. Department of Diagnostic Radiology, University of Turku and Turku University Hospital, Turku, Finland 6. Department of Radiology, Tampere University Hospital, Turku, Finland 7. Department of Endocrinology, Turku University Hospital, Turku, Finland
- ISSN:1432-0428
文摘
Aims/hypothesis Obesity causes an imbalance in fat mass distribution between visceral and subcutaneous adipose tissue (AT) depots. We tested the hypothesis that this relates to increased NEFA uptake between these depots in obese compared with healthy participants. Second, we hypothesised that a diet very low in energy (very low calorie diet [VLCD]) decreases fat mass in obese participants and that this is associated with the decline in NEFA uptake. Methods NEFA uptake in AT depots was measured with [18F]-fluoro-6-thia-heptadecanoic acid (18F-FTHA) and positron emission tomography (PET) in 18 obese participants with the metabolic syndrome before and after a 6?week VLCD. Whole body fat oxidation was measured using indirect calorimetry and [U-13C]palmitate. Sixteen non-obese participants were controls. Results Obese participants had >100% higher (p--.0001) NEFA uptake in the visceral and subcutaneous abdominal AT depots than controls. VLCD decreased AT mass in all regions (12% to 21%), but NEFA uptake was decreased significantly (18%; p--.006) only in the femoral AT. Whole body carbohydrate oxidation decreased, while fat oxidation increased. Conclusions/interpretation The data demonstrate that weight loss caused by VLCD does not affect abdominal fasting NEFA uptake rates. We found that visceral fat takes up more NEFAs than subcutaneous AT depots, even after weight loss.
| |
NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via email.
| |