Human endogenous retroviruses sustain complex and cooperative regulation of gene-containing loci and unannotated megabase-sized regions

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• 作者：Martin Sokol ; Karen Margrethe Jessen ; Finn Skou Pedersen
• 关键词：Endogenous retrovirus and endogenous retrovirus ; like repeats (ERVs) ; Chromatin immunoprecipitation with sequencing (ChIP ; seq) ; Transcription coregulation ; Paired ; end RNA ; sequencing (RNA ; seq) ; LTR12 ERV9 LTR repeat ; Alu SINE repeat ; Mammalian apparent LTR retrotransposon (MaLR) ; Chimeric and unannotated transcription
• 刊名：Retrovirology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：12
• 期：1
• 全文大小：2,123 KB
• 刊物主题：Virology; Infectious Diseases; Cancer Research;
• 出版者：BioMed Central
• ISSN：1742-4690

文摘

Background Evidence suggests that some human endogenous retroviruses and endogenous retrovirus-like repeats (here collectively ERVs) regulate the expression of neighboring genes in normal and disease states; e.g. the human globin locus is regulated by an ERV9 that coordinates long-range gene switching during hematopoiesis and activates also intergenic transcripts. While complex transcription regulation is associated with integration of certain exogenous retroviruses, comparable regulation sustained by ERVs is less understood.