Synthesis and characterization of NIR-responsive Aurod@pNIPAAm-PEGMA nanogels as vehicles for delivery of photodynamic therapy agents
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  • 作者：Ting Shang (1)
    Cai-ding Wang (1)
    Lei Ren (1) (2)
    Xin-hua Tian (3)
    Dong-hui Li (4)
    Xue-bin Ke (1)
    Min Chen (1)
    An-qi Yang (1)
  • 关键词：NIR ; responsive ; Aurod@pNIPAAm ; PEGMA nanogel ; LCST ; singlet oxygen ; PDT
  • 刊名：Nanoscale Research Letters
  • 出版年：2013
  • 出版时间：December 2013
  • 年：2013
  • 卷：8
  • 期：1
  • 全文大小：424KB
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  • 作者单位：Ting Shang (1)
    Cai-ding Wang (1)
    Lei Ren (1) (2)
    Xin-hua Tian (3)
    Dong-hui Li (4)
    Xue-bin Ke (1)
    Min Chen (1)
    An-qi Yang (1)

    1. Department of Biomaterials, Research Center of Biomedical Engineering, College of Materials, Xiamen University, Xiamen, 361005, China
    2. State Key Laboratory for Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, 361005, China
    3. Neurosurgical Department of Affiliated Zhongshan Hospital, Xiamen University, Xiamen, 361004, China
    4. College of Medicine, Xiamen University, Xiamen, 361005, China
  • ISSN：1556-276X
文摘
A near-infrared (NIR)-responsive Aurod@pNIPAAm-PEGMA nanogel was synthesized in two steps, growing a PEGMA monolayer on the surface of gold nanorods (AuNRs), followed by in situ polymerization and cross-linking of N-iso-propylacrylamide (NIPAAm) and poly-(ethylene glycol)-methacrylate (PEGMA). The AuNRs and Aurod@pNIPAAm-PEGMA nanogel were characterized by UV–vis spectroscopy, Raman spectroscopy, Fourier transform infrared spectroscopy, and transmission electron microscopy, respectively. The lower critical solution temperature of the Aurod@pNIPAAm-PEGMA nanogel could be tuned by changing the molar ratio of NIPAAm/PEGMA. The NIR-mediated drug release behavior of the Aurod@pNIPAAm-PEGMA nanogel was studied with zinc phthalocyanines (ZnPc4) as a drug model. It was also demonstrated that the loaded ZnPc4 could keep the capability of generating singlet oxygen, and the in vitro study showed a great photodynamic therapy (PDT) effect on Hela cells. It thus indicated the potential of this Aurod@pNIPAAm-PEGMA nanogel for application as a drug carrier in PDT, which might make contributions to oncotherapy.
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