Membranoproliferative Glomerulonephritis Secondary to a Low-Grade Lymphoproliferative Disorder: A Rare Cause of Renal Dysfunction

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• 作者：Tushar Sehgal ; Nidhi Jain ; Gaurav Prakash…
• 关键词：Chronic lymphocytic leukemia ; Renal dysfunction ; Membranoproliferative glomerulonephritis ; Treatment
• 刊名：Indian Journal of Hematology and Blood Transfusion
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：32
• 期：4
• 页码：494-496
• 全文大小：1,204 KB
• 刊物主题：Hematology; Oncology; Blood Transfusion Medicine; Human Genetics;
• 出版者：Springer India
• ISSN：0974-0449
• 卷排序：32

文摘

Chronic lymphocytic leukemia is a B-cell neoplasm with an indolent clinical course. Most patients are asymptomatic and are diagnosed incidentally on a routine blood count. The malignant cells of this low-grade neoplasm infiltrate various organs and tissues. However, the resultant end organ damage is a rare phenomenon. Here we describe a case of chronic lymphocytic leukemia that presented with an unusual cause of acute renal dysfunction. The patient had deranged renal parameters with a nephrotic range proteinuria. The uncommon cause for his renal problem was membranoproliferative glomerulonephritis diagnosed by performing a kidney biopsy. Moreover, the acute renal dysfunction in this patient mandated an appropriate treatment and as of now there are no well-established treatment protocols for chronic lymphocytic leukemia with nephrotic syndrome. The patient was successfully treated with rituximab and bendamustine based on the expertise and judgement of the clinician.