Relative efficacy of nicotinamide treatment of a mouse model of infantile Niemann-Pick C1 disease

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• 作者：Craig A. Marshall ; Ivan A. Borbon ; Robert P. Erickson
• 关键词：Histone deacetylase ; Nicotinamide ; Niemann ; Pick C1 disease ; Oxidative stress ; Sirtuin ; Valproic acid
• 刊名：Journal of Applied Genetics
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：58
• 期：1
• 页码：99-102
• 全文大小：
• 刊物主题：Plant Genetics & Genomics; Human Genetics; Animal Genetics and Genomics; Microbial Genetics and Genomics;
• 出版者：Springer Berlin Heidelberg
• ISSN：2190-3883
• 卷排序：58

文摘

Nicotinamide delivered in drinking water at about 2 g/kg/day significantly prolonged survival and showed a suggestive improvement on memory in the Npc1nih/ Npc1nih mouse model of infantile NPC1 disease. It is likely that this role is due to its function as a histone deacetylase (HDAC) inhibitor although another HDAC inhibitor, valproic acid, was without effect. Nicotinamide could also work by preventing/reversing oxidative stress.