Genetic clustering and polymorphism of the merozoite surface protein-3 of Plasmodium knowlesi clinical isolates from Peninsular Malaysia

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• 作者：Jeremy Ryan De Silva ; Yee Ling Lau ; Mun Yik Fong
• 关键词：Plasmodium knowlesi ; Merozoite surface protein ; 3 ; Genetic diversity ; Natural selection ; Haplotypes
• 刊名：Parasites & Vectors
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：10
• 期：1
• 全文大小：1417KB
• 刊物主题：Parasitology; Entomology; Tropical Medicine; Infectious Diseases; Veterinary Medicine/Veterinary Science; Virology;
• 出版者：BioMed Central
• ISSN：1756-3305
• 卷排序：10

文摘

BackgroundThe simian malaria parasite Plasmodium knowlesi has been reported to cause significant numbers of human infection in South East Asia. Its merozoite surface protein-3 (MSP3) is a protein that belongs to a multi-gene family of proteins first found in Plasmodium falciparum. Several studies have evaluated the potential of P. falciparum MSP3 as a potential vaccine candidate. However, to date no detailed studies have been carried out on P. knowlesi MSP3 gene (pkmsp3). The present study investigates the genetic diversity, and haplotypes groups of pkmsp3 in P. knowlesi clinical samples from Peninsular Malaysia.