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Designing Non-viral Targeted Integrating Vectors for Genome Engineering in Vertebrates
- 作者:Ludivine Sinzelle (1)
Nicolas Pollet (2) Nicolas.Pollet@issb.genopole.fr - 关键词:DNA transposons 8211 ; Zinc ; finger nuclease 8211 ; TALE 8211 ; Φ ; C31 integrase 8211 ; Meganucleases 8211 ; Site ; specific recombinases
- 刊名:Topics in Current Genetics
- 出版年:2013
- 出版时间:2013
- 年:2013
- 卷:23
- 期:1
- 页码:41-67
- 全文大小:551.8 KB
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Institute of Systems and Synthetic Biology, Genopole, CNRS, Universit茅 d鈥橢vry Val d鈥橢ssonne, Evry, France2. Institute of Systems and Synthetic Biology, Genopole, CNRS, Universit茅 d鈥橢vry Val d鈥橢ssonne, Genavenir 3, Genopole campus 1, 1, rue Pierre Fontaine, 91058 Evry, France
- ISSN:1610-6970
文摘
Genome engineering for biomedicine and biotechnology requires the integration of transgenes at specific sites in safe genomic environments. These specific integrations are needed to avoid position effects, insertional mutagenesis and chromosome abnormalities. Several efforts during the last decade led to the development of nonviral approaches based on DNA-modifying enzymes by exploiting the cellular mechanisms of cut-and-paste transposition and homologous recombination (HR). These methods include the use of zinc finger nucleases, meganucleases, site-specific recombinases such as ΦC31 integrase, Cre and Flp recombinases and transposase-based systems to achieve the integration of foreign DNA at a desired genomic position. Moreover, many teams are now investigating strategies to alter the site-specificity of these enzymes and precisely target safe insertion sites.
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