Development of poly(lactic-co-glycolic acid) microparticles with pH-sensitive drug release behaviors

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• 作者：Jung Ok Lee (1)
  Yu Seok Youn (2)
  Deok-Keun Lee (3)
  Kyung-Hoi Cha (3)
  Eun Seong Lee (1)
  
  1. Department of Biotechnology ; The Catholic University of Korea ; 43-1 Yeokgok 2-dong ; Wonmi-gu ; Bucheon ; Gyeonggi-do ; 420-743 ; Republic of Korea
  2. College of Pharmacy ; SungKyunKwan University ; 300 Chonchon-dong ; Jangan-ku ; Suwon ; Gyeonggi-do ; 440-746 ; Republic of Korea
  3. Gyeonggi Bio-Center ; Dongkook Pharm. Co ; Iui-dong ; Yeongtong-gu ; Suwon ; 443-270 ; Republic of Korea
  
• 关键词：PLGA microparticle ; 3 ; diethylaminopropylated poly(l ; lysine) ; Tiotropium
• 刊名：Journal of Pharmaceutical Investigation
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：45
• 期：2
• 页码：151-156
• 全文大小：951 KB
• 参考文献：1. Barnes, PJ (2004) Mediators of chronic obstructive pulmonary disease. Pharmacol Rev 56: pp. 515-548 24/pr.56.4.2" target="_blank" title="It opens in new window">CrossRef
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  8. Lee, ES, Park, KH, Kang, D, Park, IS, Min, HY, Lee, DH, Kim, S, Kim, JH, Na, K (2007) Protein complexed with chondroitin sulfate in poly(lactide-co-glycolide) microspheres. Biomaterials 28: pp. 2754-2762 2007.01.049" target="_blank" title="It opens in new window">CrossRef
  9. Lee, JO, Oh, KT, Kim, D, Lee, ES (2014) pH-sensitive short worm-like micelles targeting tumors based on the extracellular pH. J Mater Chem B 2: pp. 6363-6370 CrossRef
  10. Lopez, AD, Murray, CC (1998) The global burden of disease, 1990鈥?020. Nat Med 4: pp. 1241-1243 218" target="_blank" title="It opens in new window">CrossRef
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  12. Oh, KT, Oh, YT, Oh, NM, Kim, K, Lee, DH, Lee, ES (2009) A smart flower-like polymeric micelle for pH-triggered anticancer drug release. Int J Pharm 375: pp. 163-169 2009.04.005" target="_blank" title="It opens in new window">CrossRef
  13. Park, SY, Baik, HJ, Oh, YT, Oh, KT, Youn, YS, Lee, ES (2011) A smart polysaccharide/drug conjugate for photodynamic therapy. Angew Chem Int Ed 50: pp. 1644-1647 2/anie.201006038" target="_blank" title="It opens in new window">CrossRef
  14. Park, S, Kwag, DS, Lee, UY, Lee, DJ, Oh, KT, Youn, YS, Lee, ES (2014) Highly porous poly(lactide-co-glycolide) microparticles for sustained tiotropium release. Polym Advan Technol 25: pp. 16-20 2/pat.3198" target="_blank" title="It opens in new window">CrossRef
  15. Pauwels, RA, Rabe, KF (2004) Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet 364: pp. 613-620 CrossRef
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  17. Yoo, NY, Youn, YS, Oh, NM, Oh, KT, Lee, DK, Cha, KH, Oh, YT, Lee, ES (2011) Antioxidant encapsulated porous poly(lactide-co-glycolide) microparticles for developing long acting inhalation system. Colloids Surf B: Biointerfaces 88: pp. 419-424 2011.07.024" target="_blank" title="It opens in new window">CrossRef
  
• 刊物主题：Biomedicine general;
• 出版者：Springer Netherlands
• ISSN：2093-6214

文摘

We developed a novel pH-sensitive microparticle using poly(lactide-co-glycolide) (PLGA) and 3-diethylaminopropylated poly(l-lysine) [poly(Lys-DEAP)] (pKb of DEAP ~6.5). Here, the design of the microparticle takes advantage of the unique pH-sensitive feature of poly(Lys-DEAP) as either a non-ionic characteristic of DEAP moieties at pH 7.4 or an ionic characteristic of DEAP moieties at acidic pH. In particular, the ionized DEAP in PLGA microparticles modulated acidic pH-activated microparticle-destruction and allowed accelerated release of the encapsulated drug content when the pH of the solution was decreased to from 7.4 to 6.8 or 6.0. We believe that this microparticle system is expected to improve the treatment efficacy for lung diseases with chronic respiratory acidosis.