Classification and characterization of human endogenous retroviruses; mosaic forms are common

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• 作者：Laura Vargiu ; Patricia Rodriguez-Tomé ; Göran O. Sperber ; Marta Cadeddu…
• 关键词：Human endogenous retrovirus ; Classification ; Simage ; Bioinformatics ; RetroTector ; Phylogeny ; Recombination
• 刊名：Retrovirology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：13
• 期：1
• 全文大小：1,913 KB
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• 作者单位：Laura Vargiu (1) (2) (5)
  Patricia Rodriguez-Tomé (2) (5)
  Göran O. Sperber (3)
  Marta Cadeddu (1)
  Nicole Grandi (1)
  Vidar Blikstad (4)
  Enzo Tramontano (1)
  Jonas Blomberg (4)
  
  1. Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy
  2. Center for Advanced Studies, Research and Development in Sardinia, CRS4, Pula, Italy
  5. Nurideas S.r.l., Cagliari, Italy
  3. Physiology Unit, Department of Neuroscience, Uppsala University, Uppsala, Sweden
  4. Department of Medical Sciences, Uppsala University Hospital, Dag Hammarskjölds Väg 17, Uppsala, 751 85, Sweden
  
• 刊物主题：Virology; Infectious Diseases; Cancer Research;
• 出版者：BioMed Central
• ISSN：1742-4690

文摘

Background Human endogenous retroviruses (HERVs) represent the inheritance of ancient germ-line cell infections by exogenous retroviruses and the subsequent transmission of the integrated proviruses to the descendants. ERVs have the same internal structure as exogenous retroviruses. While no replication-competent HERVs have been recognized, some retain up to three of four intact ORFs. HERVs have been classified before, with varying scope and depth, notably in the RepBase/RepeatMasker system. However, existing classifications are bewildering. There is a need for a systematic, unifying and simple classification. We strived for a classification which is traceable to previous classifications and which encompasses HERV variation within a limited number of clades.