Successful treatment of osteomalacia caused by renal tubular acidosis associated with Sj?gren’s syndrome

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• 作者：Sunao Yamamoto (1)
  Yosuke Okada (1)
  Hiroko Mori (1)
  Shintaro Hirata (1)
  Kazuyoshi Saito (1)
  Nobuo Inokuchi (2)
  Yoshiya Tanaka (1)
  
• 关键词：Distal renal tubular acidosis ; Glucocorticoid ; Osteomalacia ; Sj?gren’s syndrome
• 刊名：Modern Rheumatology
• 出版年：2013
• 出版时间：March 2013
• 年：2013
• 卷：23
• 期：2
• 页码：401-405
• 全文大小：335 KB
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• 作者单位：Sunao Yamamoto (1)
  Yosuke Okada (1)
  Hiroko Mori (1)
  Shintaro Hirata (1)
  Kazuyoshi Saito (1)
  Nobuo Inokuchi (2)
  Yoshiya Tanaka (1)
  
  1. The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan
  2. Inokuchi Clinic, 10-6 Yoshino-cho, Kokurakita-ku, Kitakyusyu, 802-0085, Japan
  
• ISSN：1439-7609

文摘

A 62-year-old woman was diagnosed with severe osteomalacia caused by renal tubular acidosis associated with Sj?gren’s syndrome. She was treated with sodium bicarbonate, risedronate, alfacalcidol, and prednisolone (1?mg/kg). By 24?months, renal tubular acidosis was improved and the bone density had normalized. Here we report the successful amelioration of bone lesions through a multidisciplinary approach that improved renal tubular acidosis, with a special focus on treatment of the underlying inflammatory disorder with glucocorticoids.