The MRZ reaction in primary progressive multiple sclerosis

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• 作者：Tilman Hottenrott ; Rick Dersch ; Benjamin Berger…
• 关键词：Primary progressive multiple sclerosis ; PPMS ; Intrathecal polyspecific antiviral immune response ; MRZ reaction ; MRZR ; Oligoclonal bands ; OCB
• 刊名：Fluids and Barriers of the CNS
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：14
• 期：1
• 全文大小：968KB
• 刊物主题：Neurosciences; Hematology; Neurobiology;
• 出版者：BioMed Central
• ISSN：2045-8118
• 卷排序：14

文摘

BackgroundThe MRZ reaction (MRZR), composed of the three antibody indices (AI) against measles, rubella and varicella zoster virus and found positive in the majority of relapsing-remitting multiple sclerosis (RRMS) patients, is absent in other inflammatory neurological diseases (OIND). So far, it has been uncertain whether its differential diagnostic promise extends to patients with primary-progressive multiple sclerosis (PPMS).