The bacterial quorum-sensing molecule, N-3-oxo-dodecanoyl-l-homoserine lactone, inhibits mediator release and chemotaxis of murine mast cells

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• 作者：Ibrahim Khambati ; Sangsu Han ; Daniëlle Pijnenburg ; Hannah Jang…
• 关键词：Mast cell ; Chemotaxis ; Quorum ; sensing ; Cytokine ; Degranulation
• 刊名：Inflammation Research
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：66
• 期：3
• 页码：259-268
• 全文大小：<len>
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Immunology; Pharmacology/Toxicology; Rheumatology; Allergology; Dermatology; Neurology;
• 出版者：Springer International Publishing
• ISSN：1420-908X
• 卷排序：66

文摘

ObjectiveBacterial colonization relies on communication between bacteria via so-called “quorum-sensing molecules”, which include the acyl-homoserine lactone group. Certain acyl-homoserine lactones can modulate mammalian cell function and are thought to contribute to bacterial pathogenicity. Given the role of mast cells in host defense, we investigated the ability of acyl-homoserine lactones to modulate mast cell function.