Regioselective C-H hydroxylation of omeprazole sulfide by Bacillus megaterium CYP102A1 to produce a human metabolite

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• 作者：Hyun-Hee Jang ; Sang-Hoon Ryu ; Thien-Kim Le ; Tiep Thi My Doan…
• 关键词：CYP102A1 mutant ; Human metabolite ; Hydroxylation ; 5 ; Hydroxyomeprazole sulphide ; Omeprazole sulfide ; Regioselectivity
• 刊名：Biotechnology Letters
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：39
• 期：1
• 页码：105-112
• 全文大小：<len>
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Microbiology; Biotechnology; Applied Microbiology; Biochemistry, general;
• 出版者：Springer Netherlands
• ISSN：1573-6776
• 卷排序：39

文摘

ObjectivesTo find a simple enzymatic strategy for the efficient synthesis of the expensive 5′-hydroxyomeprazole sulfide, a recently identified minor human metabolite, from omeprazole sulfide, which is an inexpensive substrate.