Lesional cerebellar epilepsy: a review of the evidence

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• 作者：Niels A. Foit ; Vera van Velthoven ; Reinhard Schulz ; Ingmar Blümcke…
• 关键词：Cerebellum ; Epilepsy ; Surgery ; Seizures ; Hamartoma
• 刊名：Journal of Neurology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：264
• 期：1
• 页码：1-10
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Neurology; Neurosciences; Neuroradiology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-1459
• 卷排序：264

文摘

Classical teaching in epileptology localizes the origins of focal seizures solely in the cerebral cortex, with only inhibitory effects attributed to subcortical structures. However, electrophysiological and neuroimaging studies over the last decades now provide evidence for an initiation of epileptic seizures within subcortical structures. Intrinsic epileptogenicity of hypothalamic hamartoma has already been established in recognition of subcortical epilepsy, whereas a seizure-generating impact of dysplastic cerebellar lesions remains to be clarified. Herein, we examine the supportive evidence and clinical presentation of cerebellar seizures and review therapy options.