MK-801-induced impairments on the trial-unique, delayed nonmatching-to-location task in rats: effects of acute sodium nitroprusside

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• 作者：Jessica L. Hurtubise ; Wendie N. Marks ; Don A. Davies…
• 关键词：Schizophrenia ; NMDA receptor ; Nitric oxide donor ; Working memory ; Pattern separation
• 刊名：Psychopharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：234
• 期：2
• 页码：211-222
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Neurosciences; Pharmacology/Toxicology; Psychiatry;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-2072
• 卷排序：234

文摘

RationaleThe cognitive symptoms observed in schizophrenia are not consistently alleviated by conventional antipsychotics. Following a recent pilot study, sodium nitroprusside (SNP) has been identified as a promising adjunct treatment to reduce the working memory impairments experienced by schizophrenia patients.