Dietary l-cysteine inhibits d-galactosamine-induced acute liver injury in rats

详细信息    查看全文

• 作者：Seulki Lee ; Kyu-Ho Han ; Erina Yabuki ; Yumi Nakamura…
• 关键词：antioxidant ; l ; cysteine ; rat ; d ; galactosamine ; gluthathione
• 刊名：Food Science and Biotechnology
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：24
• 期：3
• 页码：1151-1157
• 全文大小：330 KB
• 参考文献：1.Salmon AB, Richardson A, P茅rez VI. Update on the oxidative stress theory of aging: Does oxidative stress play a role in aging or healthy aging. Free Radical Bio. Med. 48: 642鈥?55 (2010)View Article
  2.Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling. Am. J. Physiol.-Lung C. 279: L1005-L1028 (2000)
  3.Martins EA, Chubatsu LS, Meneghini R. Role of antioxidants in protecting cellular DNA from damage by oxidative stress. Mutat. Res.-Fund. Mol. M. 250: 95鈥?01 (1991)View Article
  4.O'Donovan DJ, Fernandes CJ. Mitochondrial glutathione and oxidative stress: Implications for pulmonary oxygen toxicity in premature infants. Mol. Genet. Metab. 71: 352鈥?58 (2000)View Article
  5.Meredith MJ, Reed DJ. Depletion in vitro of mitochondrial glutathione in rat hepatocytes and enhancement of lipid peroxidation by adriamycin and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Biochem. Pharmacol. 32: 1383鈥?388 (1983)View Article
  6.Han D, Sen CK, Roy S, Kobayashi MS, Tritschler HJ, Packer L. Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants. Am. J. Physiol.-Reg. I. 273: R1771-R1778 (1997)
  7.Youn SH, Park HW, Shin CS. Enhanced dissolution of the substrate d,l-2-amino-螖2-thiazoline-4-carboxylic acid and enzymatic production of L-cysteine at high concentrations. Eng. Life Sci. 12: 514鈥?17 (2012)View Article
  8.Kim YG, Kim SK, Kwon JW, Park OJ, Kim SG, Kim YC, Lee MG. Effects of cysteine on amino acid concentrations and transsulfuration enzyme activities in rat liver with protein-calorie malnutrition. Life Sci. 72: 1171鈥?181 (2003)View Article
  9.Tateishi N, Higashi T, Naruse A, Nakashima K, Shiozaki H. Ratliver glutathione: Possible role as a reservoir of cysteine. J. Nutr. 107: 51鈥?0 (1977)
  10.Nandi D, Patra RC, Swarup D. Effect of cysteine, methionine, ascorbic acid and thiamine on arsenic-induced oxidative stress and biochemical alterations in rats. Toxicology 211: 26鈥?5 (2005)View Article
  11.Dilger RN, Toue S, Kimura T, Sakai R, Baker DH. Excess dietary l -cysteine, but not L-cystine, is lethal for chicks but not for rats or pigs. J. Nutr. 137: 331鈥?38 (2007)
  12.Lee S, Han KH, Nakamura Y, Kawakami S, Shimada K, Hayakawa T, Onoue H, Fukushima M. Dietary l -cysteine improves the antioxidative potential and lipid metabolism in rats fed a normal diet. Biosci. Biotech. Bioch. 77: 1430鈥?434 (2013)View Article
  13.Chalasani N, Deeg MA, Crabb DW. Systemic levels of lipid peroxidation and its metabolic and dietary correlates in patients with nonalcoholic steatohepatitis. Am. J. Gastroenterol. 99: 1497鈥?502 (2004)View Article
  14.Simon JB. Acetaminophen liver injury. Can. Fam. Physician 31: 2155鈥?156 (1985)
  15.Geubel AP, De Galocsy C, Alves N, Rahier J, Dive C. Liver damage caused by therapeutic vitamin A administration: Estimate of dose-related toxicity in 41 cases. Gastroenterology 100: 1701鈥?709 (1991)
  16.Coen M, Want EJ, Clayton TA, Rhode CM, Hong YS, Keun HC, Cantor GH, Metz AL, Robertson DG, Reily MD, Holmes E, Lindon JC, Nicholson JK. Mechanistic aspects and novel biomarkers of responder and non-responder phenotypes in galactosamine-induced hepatitis. J. Proteome Res. 8: 5175鈥?187 (2009)View Article
  17.National Research Council. Guide for the care and use of laboratory animals. Available from: http://鈥媤ww.鈥媙ap.鈥媏du/鈥媜penbook.鈥媝hp?鈥媟ecord_鈥媔d =5140. Acceessed Apr. 1, 2011.
  18.Aebi H. Methods of Enzymatic Analysis. Academic Press, New York, NY, USA. pp. 673鈥?84 (1974)
  19.Worthington DJ, Rosemeyer MA. Human glutathione reductase: Purification of the crystalline enzyme from erythrocytes. Eur. J. Biochem. 48: 167鈥?77 (1974)View Article
  20.Lawrence RA, Burk RF. Glutathione peroxidase activity in selenium-deficient rat liver. Biochem. Bioph. Res. Co. 71: 952鈥?58 (1976)View Article
  21.Cohn VH, Lyle J. A fluorometric assay for glutathione. Anal. Biochem. 14: 434鈥?40 (1966)View Article
  22.Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95: 351鈥?58 (1979)View Article
  23.Tanaka E, Hagino S, Yoshida T, Kuroiwa Y, Ohno H, Numata H. The protective effect of cysteine on chemical-induced liver injury in rats. J. Toxicol. Sci. 9: 245鈥?51 (1984)View Article
  24.Awe S, Olayinka ET. Effect of cashew wine on histology and enzyme activities of rat liver. J. Toxicol. Environ. Health Sci. 3: 31鈥?8(2011)
  25.Se莽kin S, Alsancak S, Basaran K眉莽眉kergin C, Aydin M. Effect of Dgalactosamine on oxidative stress and apoptosis in the liver of rats. J. Ist. Faculty Med. 71: 29鈥?2 (2008)
  26.Hu HL, Chen RD. Changes in free radicals, trace elements, and neurophysiological function in rats with liver damage induced by Dgalactosamine. Biol. Trace Elem. Res. 34: 19鈥?5 (1992)View Article
  27.Forsberg L, de Faire U, Morgenstern R. Low yield of polymorphisms from EST blast searching: analysis of genes related to oxidative stress and verication of the P197L polymorphism in GPX1. Hum. Mutat. 13: 294鈥?00 (1999)View Article
  28.Bostwick DG, Alexander EE, Singh R, Shan A, Qian J, Santella RM, Oberley LW, Yan T, Zhong W, Jiang X, Oberley TD. Antioxidant enzyme expression and reactive oxygen species damage in prostatic initraepithelial neoplasia and cancer. Cancer 89: 123鈥?34 (2000)View Article
  29.Vimal V, Devaki T. Hepatoprotective effect of allicin on tissue defense system in galactosamine/endotoxin challenged rats. J. Ethnopharmacol. 90: 151鈥?54 (2004)View Article
  30.Choi SH, Park KH. Protective Effects of Angelica keiskei extracts against d -galactosamine (GalN)-induced hepatotoxicity in rats. J. Fd. Hyg. Safety 26: 235鈥?41 (2011)
  31.Ohba K, Nirei M, Watanabe S, Han KH, Hashimoto N, Shimada K, Sekikawa M, Chiji H, Fukushima M. Effect of an adzuki bean extract on hepatic anti-oxidant enzyme mRNAs in d -galactosamine-treated rats. Biosci. Biotech. Bioch. 69: 1988鈥?991 (2005)View Article
  32.Shimoda H, Tanaka J, Kikuchi M, Fukuda T, Ito H, Hatano T, Yoshida T. Walnut polyphenols6 prevent liver damage induced by carbon tetrachloride and d -galactosamine: Hepatoprotective hydrolyzable tannins in the kernel pellicles of walnut. J. Agr. Food Chem. 56: 4444鈥?449 (2008)View Article
  33.Lee SK, Kang MJ, Jeon TW, Jeong TC. Effects of N-acetyl cysteine and silymarin on 1
  omopropane-induced hepatotoxicity in mice. Yakhak Hoeji 54: 97鈥?01 (2010)
  34.Patterson RA, Lamb DJ, Leake DS. Mechanisms by which cysteine can inhibit or promote the oxidation of low density lipoprotein by copper. Atherosclerosis 169: 87鈥?4 (2003)View Article
  35.Ohta Y, Matsura T, Kitagawa A, Tokunaga K, Yamada K. Xanthine oxidase-derived reactive oxygen species contribute to the development of d -galactosamine-induced liver injury in rats. Free Radical Res. 41: 135鈥?44 (2007)View Article
  36.Al-Mustafa ZH, Al-Ali AK, Qaw FS, Abdul-Cader Z. Cimetidine enhances the hepatoprotective action of N-acetyl cysteine in mice treated with toxic doses of paracetamol. Toxicology 121: 223鈥?28 (1997)View Article
  37.Wong CK, Ooi VEC, Wong CK. Protective effects of N-acetyl cysteine against carbon tetrachloride and trichloroethyleneinduced poisoning in rats. Environ. Toxicol. Phar. 14: 109鈥?16 (2003)View Article
  38.Price VF, Jollow DJ. Effects of sulfur-amino acid-deficient diets on acetaminophen metabolism and hepatotoxicity in rats. Toxicol. Appl. Pharm. 101: 356鈥?69 (1989)View Article
  39.Tsutsui S, Hirasawa K, Takeda M, Itagaki S, Kawamura S, Maeda K, Mikami T, Doi K. Apoptosis of murine hepatocytes induced by high doses of galactosamine. J. Vet. Med. Sci. 59: 785鈥?90 (1997)View Article
  40.McMillan JM, Jollow DJ. Galactosamine hepatotoxixity: Effect of galactosamine on glutathione resynthesis in rat primary hepatocyte cultures. Toxicol. Appl. Pharm. 115: 234鈥?40 (1992)View Article
  41.Blouet C, Mariotti F, Azzout-Marniche D, Math茅 V, Mikogami T, Tom茅 D, Huneau JF. Dietary cysteine alleviates sucrose-induced oxidative stress and insulin resistance. Free Radical Bio. Med. 42: 1089鈥?097 (2007)View Article
  42.Burgunder JM, Varriale A, Lauterburg BH. Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration. Eur. J. Clin. Pharmacol. 36: 127鈥?31 (1989)View Article
  
• 作者单位：Seulki Lee (1)
  Kyu-Ho Han (1) (2)
  Erina Yabuki (2)
  Yumi Nakamura (2)
  Sakura Kawakami (2)
  Kenichiro Shimada (2)
  Toru Hayakawa (3)
  Hirotake Onoue (4)
  Michihiro Fukushima (1) (2)
  
  1. Department of Bioresources Science, The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate, 020-8550, Japan
  2. Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, 080-8555, Japan
  3. Department of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, 080-8555, Japan
  4. Tomo Chemical Co., Ltd., Tokyo, 102-0082, Japan
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nutrition
  Food Science
  
• 出版者：The Korean Society of Food Science and Technology in co-publication with Springer
• ISSN：2092-6456

文摘

The effects of l-cysteine (1 and 2%) on the antioxidative system were examined in rats with d-galactosamine (d-GalN)-induced injury. These rats showed increases in serum antioxidative enzyme and hepatic thiobarbituric acid reactive substances (TBARS) activities, with decreased hepatic/serum glutathione (GSH) levels and GSH-related enzyme activities. However, l-cysteine supplementation resulted in a decrease of hepatic TBARS levels, and increased catalase and serum GSH levels. The activities of serum enzymes in rats receiving 2% l-cysteine were significantly (p<0.05) lower than in d-GalN-injected group rats, and similar to levels in control group rats without acute liver injury. In addition, 2% l-cysteine increased the glutathione reductase activity and decreased the serum TBARS level in liver injury group rats. Dietary l-cysteine, especially at a 2% level, exerts a hepatoprotective effect by alteration of the GSH level and antioxidative enzyme activities.