Encapsulation of Sorbitan Ester-Based Organogels in Alginate Microparticles

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• 作者：Sai S. Sagiri (1)
  Kunal Pal (1)
  Piyali Basak (2)
  Usman Ali Rana (3)
  Imran Shakir (3)
  Arfat Anis (4)
  
• 关键词：alginate ; drug delivery ; leaching ; microparticles ; organogels
• 刊名：AAPS PharmSciTech
• 出版年：2014
• 出版时间：October 2014
• 年：2014
• 卷：15
• 期：5
• 页码：1197-1208
• 全文大小：3,124 KB
• 参考文献：1. Chan LW, Lee HY, Heng PWS. Production of alginate microspheres by internal gelation using an emulsification method. Int J Pharm. 2002;242(1鈥?):259鈥?2. doi:10.1016/S0378-5173(02)00170-9 . CrossRef
  2. Sansone F, Mencherini T, Picerno P, d鈥橝more M, Aquino RP, Lauro MR. Maltodextrin/pectin microparticles by spray drying as carrier for nutraceutical extracts. J Food Eng. 2011;105(3):468鈥?6. CrossRef
  3. Sansukcharearnpon A, Wanichwecharungruang S, Leepipatpaiboon N, Kerdcharoen T, Arayachukeat S. High loading fragrance encapsulation based on a polymer-blend: preparation and release behavior. Int J Pharm. 2010;391(1):267鈥?3. CrossRef
  4. Cocero MJ, Mart铆n 脕, Mattea F, Varona S. Encapsulation and co-precipitation processes with supercritical fluids: fundamentals and applications. J Supercrit Fluids. 2009;47(3):546鈥?5. CrossRef
  5. Sagiri SS, Behera B, Sudheep T, Pal K. Effect of composition on the properties of tween-80鈥搒pan-80-based organogels. Des Monomers Polym. 2012;15(3):253鈥?3. doi:10.1163/156855511X615669 . CrossRef
  6. Pouton CW, Porter CJ. Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies. Adv Drug Deliv Rev. 2008;60(6):625鈥?7. CrossRef
  7. Peshkovsky AS, Peshkovsky SL, Bystryak S. Scalable high-power ultrasonic technology for the production of translucent nanoemulsions. Chem Eng Process Process Intensif. 2013;69:77鈥?2. CrossRef
  8. Sagiri SS, Sethy J, Pal K, Banerjee I, Pramanik K, Maiti TK. Encapsulation of vegetable organogels for controlled delivery applications. Des Monomers Polym. 2012;16(4):366鈥?76. doi:10.1080/15685551.2012.747154 .
  9. Simonoska Crcarevska M, Glavas Dodov M, Goracinova K. Chitosan coated Ca鈥揳lginate microparticles loaded with budesonide for delivery to the inflamed colonic mucosa. Eur J Pharm Biopharm. 2008;68(3):565鈥?8. doi:10.1016/j.ejpb.2007.06.007 . CrossRef
  10. Bordenave N, Janaswamy S, Yao Y. Influence of glucan structure on the swelling and leaching properties of starch microparticles. Carbohydr Polym. 2014;103:234鈥?3. CrossRef
  11. Kulkarni AR, Soppimath KS, Aminabhavi TM, Rudzinski WE. In-vitro release kinetics of cefadroxil-loaded sodium alginate interpenetrating network beads. Eur J Pharm Biopharm. 2001;51(2):127鈥?3. CrossRef
  12. Meerloo J, Kaspers GL, Cloos J. Cell sensitivity assays: the MTT assay. In: Cree IA, editor. Cancer cell culture. Humana Press; 2011. p. 237鈥?5.
  13. Martins S, Sarmento B, Souto EB, Ferreira DC. Insulin-loaded alginate microspheres for oral delivery鈥攅ffect of polysaccharide reinforcement on physicochemical properties and release profile. Carbohydr Polym. 2007;69(4):725鈥?1. doi:10.1016/j.carbpol.2007.02.012 . CrossRef
  14. Gavini E, Sanna V, Sharma R, Juliano C, Usai M, Marchetti M, / et al. Solid lipid microparticles (SLM) containing juniper oil as anti-acne topical carriers: preliminary studies. Pharm Dev Technol. 2005;10(4):479鈥?7. doi:10.1080/10837450500299727 . CrossRef
  15. Maji TK, Baruah I, Dube S, Hussain MR. Microencapsulation of / Zanthoxylum limonella oil (ZLO) in glutaraldehyde crosslinked gelatin for mosquito repellent application. Bioresour Technol. 2007;98(4):840鈥?. doi:10.1016/j.biortech.2006.03.005 . CrossRef
  16. Behera B, Sagiri SS, Pal K, Srivastava A. Modulating the physical properties of sunflower oil and sorbitan monopalmitate-based organogels. J Appl Polym Sci. 2013;127(6):4910鈥?. CrossRef
  17. Parashar BN, Mittal R. Elements of manufacturing processes. New Delhi: PHI Learning Pvt, Ltd.; 2002.
  18. Dong Z, Wang Q, Du Y. Alginate/gelatin blend films and their properties for drug controlled release. J Membr Sci. 2006;280(1鈥?):37鈥?4. CrossRef
  19. Tam SK, Dusseault J, Polizu S, M茅nard M, Hall茅 J-P, Yahia LH. Physicochemical model of alginate鈥損oly-l-lysine microcapsules defined at the micrometric/nanometric scale using ATR-FTIR, XPS, and ToF-SIMS. Biomaterials. 2005;26(34):6950鈥?1. CrossRef
  20. Jia-hui Y, Yu-min D, Hua Z. Blend films of chitosan-gelatin. Wuhan Univ J Nat Sci. 1999;4(4):476. CrossRef
  21. Coates J. Interpretation of infrared spectra, a practical approach. Encyclopedia of analytical chemistry. Chichester: Wiley; 2006.
  22. Vaidya A, Jain S, Agrawal RK, Jain SK. Pectin鈥搈etronidazole prodrug bearing microspheres for colon targeting. J Saudi Chem Soc. doi:10.1016/j.jscs.2012.03.001 .
  23. Suzuki M, Nakajima Y, Yumoto M, Kimura M, Shirai H, Hanabusa K. Effects of hydrogen bonding and van der Waals interactions on organogelation using designed low-molecular-weight gelators and gel formation at room temperature. Langmuir. 2003;19(21):8622鈥?. CrossRef
  24. Ramesh Babu V, Sairam M, Hosamani KM, Aminabhavi TM. Preparation of sodium alginate鈥搈ethylcellulose blend microspheres for controlled release of nifedipine. Carbohydr Polym. 2007;69(2):241鈥?0. CrossRef
  25. Ostrowska-Czubenko J, Gierszewska-Dru偶y艅ska M. Effect of ionic crosslinking on the water state in hydrogel chitosan membranes. Carbohydr Polym. 2009;77(3):590鈥?. CrossRef
  26. Yamashita S, Kataoka M, Higashino H, Sakuma S, Sakamoto T, Uchimaru H, / et al. Measurement of drug concentration in the stomach after intragastric administration of drug solution to healthy volunteers: analysis of intragastric fluid dynamics and drug absorption. Pharm Res. 2013;30(4):951鈥?58.
  27. Radin S, Chen T, Ducheyne P. The controlled release of drugs from emulsified, sol gel processed silica microspheres. Biomaterials. 2009;30(5):850鈥?. CrossRef
  28. Cui J-H, Goh J-S, Kim P-H, Choi S-H, Lee B-J. Survival and stability of bifidobacteria loaded in alginate poly-l-lysine microparticles. Int J Pharm. 2000;210(1鈥?):51鈥?. CrossRef
  29. Pasparakis G, Bouropoulos N. Swelling studies and in vitro release of verapamil from calcium alginate and calcium alginate鈥揷hitosan beads. Int J Pharm. 2006;323(1鈥?):34鈥?2. doi:10.1016/j.ijpharm.2006.05.054 . CrossRef
  
• 作者单位：Sai S. Sagiri (1)
  Kunal Pal (1)
  Piyali Basak (2)
  Usman Ali Rana (3)
  Imran Shakir (3)
  Arfat Anis (4)
  
  1. Department of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela, 769008, India
  2. School of Bioscience & Engineering, Jadavpur University, Kolkata, 700032, India
  3. Deanship of Scientific Research, College of Engineering, King Saud University, Riyadh, 11421, Saudi Arabia
  4. Department of Chemical Engineering, King Saud University, Riyadh, 11421, Saudi Arabia
  
• ISSN：1530-9932

文摘

Leaching of the internal apolar phase from the biopolymeric microparticles during storage is a great concern as it undoes the beneficial effects of encapsulation. In this paper, a novel formulation was prepared by encapsulating the sunflower oil-based organogels in alginate microparticles. Salicylic acid and metronidazole were used as the model drugs. The microparticles were prepared by double emulsion methodology. Physico-chemical characterization of the microparticles was done by microscopy, FTIR, XRD, and DSC studies. Oil leaching studies, biocompatibility, mucoadhesivity, in vitro drug release, and the antimicrobial efficiency of the microparticles were also performed. The microparticles were found to be spherical in shape. Gelation of the sunflower oil prevented leaching of the internal phase from the microparticles. Release of drugs from the microparticles followed Fickian kinetics and non-Fickian kinetics in gastric and intestinal environments, respectively. Microparticles showed good antimicrobial activity against both Gram-positive (Bacillus subtilis) and Gram-negative (Escherichia coli) bacteria. The results suggested that the developed formulations hold promise to carry oils without leakage of the internal phase. Encapsulation of organogels within the microparticles has improved the drug entrapment efficiency and improved characteristics for controlled delivery applications.