Valsartan blocks thrombospondin/transforming growth factor/Smads to inhibit aortic remodeling in diabetic rats

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• 作者：Hui Sun ; Yong Zhao ; Xiuping Bi ; Shaohua Li ; Guohai Su ; Ya Miao…
• 关键词：Diabetes ; Macrovascular remodeling ; Thrombospondin 1 ; Transforming growth factor β1 ; Smads ; valsartan
• 刊名：Diagnostic Pathology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：10
• 期：1
• 全文大小：1,525 KB
• 刊物主题：Pathology;
• 出版者：BioMed Central
• ISSN：1746-1596

文摘

Background Angiotensin II (Ang II) and transforming growth factor β (TGFβ) are closely involved in the pathogenesis of diabetic complications. We aimed to determine whether an aberrant thrombospondin 1 (TSP1)–mediated TGFβ1/Smads signaling pathway specifically affects vascular fibrosis in diabetic rats and whether valsartan, an Ang II subtype 1 receptor blocker, has an anti-fibrotic effect.