Expression of stromal cell-derived factor 1 and CXCR7 ligand receptor system in pancreatic adenocarcinoma

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• 作者：Zhen Liu (2) r> Xu-Yong Teng (2) r> Xiang-Peng Meng (2) r> Bao-Sheng Wang (2) r>r>2. Department of General Surgery ; Shengjing Hospital ; China Medical University ; No. 36 Sanhao Street ; Shenyang ; 110004 ; China r>
• 关键词：chemokine ; chemokine receptors ; CXCR7 ; pancreatic neoplasms ; SDF ; 1
• 刊名：World Journal of Surgical Oncology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：12
• 期：1
• 全文大小：653 KB
• 参考文献：1. Bleul, CC, Fuhlbrigge, RC, Casasnovas, JM, Aiuti, A, Springer, TA (1996) A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). J Exp Med 184: pp. 1101-1109 rnal" href="http://dx.doi.org/10.1084/jem.184.3.1101" target="_blank" title="It opens in new window">CrossRef r> 2. Ara, T, Nakamura, Y, Egawa, T, Sugiyama, T, Abe, K, Kishimoto, T, Matsui, Y, Nagasawa, T (2003) Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1). Proc Natl Acad Sci USA 100: pp. 5319-5323 rnal" href="http://dx.doi.org/10.1073/pnas.0730719100" target="_blank" title="It opens in new window">CrossRef r> 3. Askari, AT, Unzek, S, Popovic, ZB, Goldman, CK, Forudi, F, Kiedrowski, M, Rovner, A, Ellis, SG, Thomas, JD, DiCorleto, PE, Topol, EJ, Penn, MS (2003) Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy. Lancet 362: pp. 697-703 rnal" href="http://dx.doi.org/10.1016/S0140-6736(03)14232-8" target="_blank" title="It opens in new window">CrossRef r> 4. Ma, Q, Jones, D, Borghesani, PR, Nagasawa, T, Kishimoto, T, Bronson, RT, Springer, TA (1998) Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci USA 95: pp. 9448-9453 rnal" href="http://dx.doi.org/10.1073/pnas.95.16.9448" target="_blank" title="It opens in new window">CrossRef r> 5. Aiuti, A, Webb, IJ, Bleul, C, Springer, T, Gutierrez-Ramos, JC (1997) The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. J Exp Med 185: pp. 111-120 rnal" href="http://dx.doi.org/10.1084/jem.185.1.111" target="_blank" title="It opens in new window">CrossRef r> 6. Nagasawa, T, Hirota, S, Tachibana, K, Takakura, N, Nishikawa, S, Kitamura, Y, Yoshida, N, Kikutani, H, Kishimoto, T (1996) Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382: pp. 635-638 rnal" href="http://dx.doi.org/10.1038/382635a0" target="_blank" title="It opens in new window">CrossRef r> 7. Miao, Z, Luker, KE, Summers, BC, Berahovich, R, Bhojani, MS, Rehemtulla, A, Kleer, CG, Essner, JJ, Nasevicius, A, Luker, GD, Howard, MC, Schall, TJ (2007) CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature. Proc Natl Acad Sci USA 104: pp. 15735-15740 rnal" href="http://dx.doi.org/10.1073/pnas.0610444104" target="_blank" title="It opens in new window">CrossRef r> 8. Marchesi, F, Monti, P, Leone, BE, Zerbi, A, Vecchi, A, Piemonti, L, Mantovani, A, Allavena, P (2004) Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4. Cancer Res 64: pp. 8420-8427 rnal" href="http://dx.doi.org/10.1158/0008-5472.CAN-04-1343" target="_blank" title="It opens in new window">CrossRef r> 9. Sutton, A, Friand, V, Brul茅-Donneger, S, Chaigneau, T, Ziol, M, Sainte-Catherine, O, Poir茅, A, Saffar, L, Kraemer, M, Vassy, J, Nahon, P, Salzmann, JL, Gattegno, L, Charnaux, N (2007) Stromal cell-derived factor-1/chemokine (C-X-C motif) ligand 12 stimulates human hepatoma cell growth, migration, and invasion. Mol Cancer Res 5: pp. 21-33 rnal" href="http://dx.doi.org/10.1158/1541-7786.MCR-06-0103" target="_blank" title="It opens in new window">CrossRef r> 10. Burns, JM, Summers, BC, Wang, Y, Melikian, A, Berahovich, R, Miao, Z, Penfold, ME, Sunshine, MJ, Littman, DR, Kuo, CJ, Wei, K, McMaster, BE, Wright, K, Howard, MC, Schall, TJ (2006) A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J Exp Med 203: pp. 2201-2213 rnal" href="http://dx.doi.org/10.1084/jem.20052144" target="_blank" title="It opens in new window">CrossRef r> 11. Wang, J, Shiozawa, Y, Wang, J, Wang, Y, Jung, Y, Pienta, KJ, Mehra, R, Loberg, R, Taichman, RS (2008) The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer. J Biol Chem 283: pp. 4283-4294 rnal" href="http://dx.doi.org/10.1074/jbc.M707465200" target="_blank" title="It opens in new window">CrossRef r> 12. Rot, A, von Andrian, UH (2004) Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu Rev Immunol 22: pp. 891-928 rnal" href="http://dx.doi.org/10.1146/annurev.immunol.22.012703.104543" target="_blank" title="It opens in new window">CrossRef r> 13. Luther, SA, Cyster, JG (2001) Chemokines as regulators of T cell differentiation. Nat Immunol 2: pp. 102-107 rnal" href="http://dx.doi.org/10.1038/84205" target="_blank" title="It opens in new window">CrossRef r> 14. Kulbe, H, Levinson, NR, Balkwill, F, Wilson, JL (2004) The chemokine network in cancer - much more than directing cell movement. Int J Dev Biol 48: pp. 489-496 rnal" href="http://dx.doi.org/10.1387/ijdb.041814hk" target="_blank" title="It opens in new window">CrossRef r> 15. Vicari, AP, Caux, C (2002) Chemokines in cancer. Cytokine Growth Factor Rev 13: pp. 143-154 rnal" href="http://dx.doi.org/10.1016/S1359-6101(01)00033-8" target="_blank" title="It opens in new window">CrossRef r> 16. Geminder, H, Sagi-Assif, O, Goldberg, L, Meshel, T, Rechavi, G, Witz, IP, Ben-Baruch, A (2001) A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases in neuroblastoma. J Immunol 167: pp. 4747-4757 rnal" href="http://dx.doi.org/10.4049/jimmunol.167.8.4747" target="_blank" title="It opens in new window">CrossRef r> 17. Kryczek, I, Lange, A, Mottram, P, Alvarez, X, Cheng, P, Hogan, M, Moons, L, Wei, S, Zou, L, Machelon, V, Emilie, D, Terrassa, M, Lackner, A, Curiel, TJ, Carmeliet, P, Zou, W (2005) CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers. Cancer Res 65: pp. 465-472 r> 18. Meijer, J, Ogink, J, Roos, E (2008) Effect of the chemokine receptor CXCR7 on proliferation of carcinoma cells in vitro and in vivo. Br J Cancer 99: pp. 1493-1501 rnal" href="http://dx.doi.org/10.1038/sj.bjc.6604727" target="_blank" title="It opens in new window">CrossRef r> 19. Zheng, K, Li, HY, Su, XL, Wang, XY, Tian, T, Li, F, Ren, GS (2010) Chemokine receptor CXCR7 regulates the invasion, angiogenesis and tumor growth of human hepatocellular carcinoma cells. J Exp Clin Cancer Res 29: pp. 31 rnal" href="http://dx.doi.org/10.1186/1756-9966-29-31" target="_blank" title="It opens in new window">CrossRef r> 20. Schutyser, E, Su, Y, Yu, Y, Gouwy, M, Zaja-Milatovic, S, Van Damme, J, Richmond, A (2007) Hypoxia enhances CXCR4 expression in human microvascular endothelial cells and human melanoma cells. Eur Cytokine Netw 18: pp. 59-70 r> 21. Goldmann, T, Dr脰mann, D, Radtke, J, Marwitz, S, Lang, DS, Schultz, H, Vollmer, E (2008) CXCR7 transcription in human non-small cell lung cancer and tumor-free lung tissues; possible regulation upon chemotherapy. Virchows Arch 452: pp. 347-348 rnal" href="http://dx.doi.org/10.1007/s00428-008-0579-8" target="_blank" title="It opens in new window">CrossRef r> 22. Mar茅chal, R, Demetter, P, Nagy, N, Berton, A, Decaestecker, C, Polus, M, Closset, J, Devi猫re, J, Salmon, I, Van Laethem, JL (2009) High expression of CXCR4 may predict poor survival in resected pancreatic adenocarcinoma. Br J Cancer 100: pp. 1444-1451 rnal" href="http://dx.doi.org/10.1038/sj.bjc.6605020" target="_blank" title="It opens in new window">CrossRef r> 23. Riediger, H, Keck, T, Wellner, U, zur Hausen, A, Adam, U, Hopt, UT, Makowiec, F (2009) The lymph node ratio is the strongest prognostic factor after resection of pancreatic cancer. J Gastrointest Surg 13: pp. 1337-1344 rnal" href="http://dx.doi.org/10.1007/s11605-009-0919-2" target="_blank" title="It opens in new window">CrossRef r> 24. Fujita, T, Nakagohri, T, Gotohda, N, Takahashi, S, Konishi, M, Kojima, M, Kinoshita, T (2010) Evaluation of the prognostic factors and significance of lymph node status in invasive ductal carcinoma of the body or tail of the pancreas. Pancreas 39: pp. 48-54 rnal" href="http://dx.doi.org/10.1097/MPA.0b013e3181bd5cfa" target="_blank" title="It opens in new window">CrossRef r>
• 刊物主题：Surgical Oncology;
• 出版者：BioMed Central
• ISSN：1477-7819

文摘

Background Stromal cell-derived factor 1 (SDF-1) is a chemokine that is expressed in some cancer cells and is involved in tumor cell migration and metastasis. CXCR7, a novel receptor for SDF-1, has been identified recently. Research has demonstrated that SDF-1/CXCR7 interaction could play an important role in cancer progression. In this study, we aimed to investigate the expression of the SDF-1/CXCR7 ligand receptor system and the relationship between this expressions and clinicopathological characteristics in pancreatic adenocarcinoma. Methods Expressions of SDF-1 and CXCR7 in 64 cases of pancreatic adenocarcinoma tissue and 24 cases of normal pancreatic tissue were detected immunohistochemically. Results Expressions of SDF-1 and CXCR7 were negative in normal pancreatic tissues. Respectively, positive expression rates of SDF-1 and CXCR7 in pancreatic adenocarcinoma were 45.3% and 51.6%. The expression of SDF-1 correlated with histological grades; the expression rate in moderate to low differentiation was higher than in high differentiation (P P SDF-1+/CXCR7+ correlated with poor prognosis (P Conclusions The SDF-1/CXCR7 receptor ligand system may take part in invasive progression and metastasis of pancreatic adenocarcinoma, and might be useful as an index for evaluating invasiveness and prognosis.