AP endonuclease 1 as a key enzyme in repair of apurinic/apyrimidinic sites

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• 作者：N. S. Dyrkheeva ; N. A. Lebedeva ; O. I. Lavrik
• 关键词：human apurinic/apyrimidinic endonuclease 1 (APE1) ; AP site ; base excision repair ; protein–DNA interactions ; protein–protein interactions
• 刊名：Biochemistry (Moscow)
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：81
• 期：9
• 页码：951-967
• 全文大小：936 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Bioorganic Chemistry
  Microbiology
  Biomedicine
  Russian Library of Science
  
• 出版者：MAIK Nauka/Interperiodica distributed exclusively by Springer Science+Business Media LLC.
• ISSN：1608-3040
• 卷排序：81

文摘

Human apurinic/apyrimidinic endonuclease 1 (APE1) is one of the key participants in the DNA base excision repair system. APE1 hydrolyzes DNA adjacent to the 5′-end of an apurinic/apyrimidinic (AP) site to produce a nick with a 3′-hydroxyl group and a 5′-deoxyribose phosphate moiety. APE1 exhibits 3′-phosphodiesterase, 3′-5′-exonuclease, and 3-phosphatase activities. APE1 was also identified as a redox factor (Ref-1). In this review, data on the role of APE1 in the DNA repair process and in other metabolic processes occurring in cells are analyzed as well as the interaction of this enzyme with DNA and other proteins participating in the repair system.