Production of 61Cu by the natZn(p,α) reaction: improved separation and specific activity determination by titration with three chelators

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• 作者：Ali H. Asad ; Suzanne V. Smith…
• 关键词：61Cu ; natZn ; 64Zn ; Specific activity ; ICP ; MS ; Bifunctional chelators
• 刊名：Journal of Radioanalytical and Nuclear Chemistry
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：307
• 期：2
• 页码：899-906
• 全文大小：636 KB
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• 作者单位：Ali H. Asad (1) (2)
  Suzanne V. Smith (3)
  Laurence M. Morandeau (1)
  Sun Chan (1)
  Charmaine M. Jeffery (1)
  Roger I. Price (1) (4)
  
  1. Radiopharmaceutical Production & Development (RAPID) Laboratory, Medical Technology and Physics, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Perth, WA, 6009, Australia
  2. Department of Imaging & Applied Physics, Curtin University, Perth, WA, 6845, Australia
  3. Medical Isotope Research and Production Program, Collider-Accelerator Department, Brookhaven National Laboratory, Upton, NY, 11973, USA
  4. School of Physics, University of Western Australia, Nedlands, WA, 6009, Australia
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nuclear Chemistry
  Physical Chemistry
  Nuclear Physics, Heavy Ions and Hadrons
  Diagnostic Radiology
  Inorganic Chemistry
  
• 出版者：Akad茅miai Kiad贸, co-published with Springer Science+Business Media B.V., Formerly Kluwer Academic
• ISSN：1588-2780

文摘

The cyclotron-based production of positron-emitting 61Cu using the (p,α) reaction at 11.7 MeV was investigated starting from natural-zinc (natZn) and enriched 64Zn-foil targets, as well as its subsequent purification. For natZn, a combination of three resins were assessed to separate 61Cu from contaminating 66,67,68Ga and natZn. The specific activity of the purified 61Cu determined using ICP-MS analysis ranged from 143.3 ± 14.3(SD) to 506.2 ± 50.6 MBq/µg while the titration method using p-SCN-Bn-DOTA, p-SCN-Bn-NOTA and diamsar gave variable results (4.7 ± 0.2–412.5 ± 15.3 MBq/µg), with diamsar lying closest to the ICP-MS values. Results suggest that the p-SCN-Bn-DOTA and p-SCN-Bn-NOTA titration methods are significantly affected by the presence of trace-metal contaminants. Keywords 61Cu natZn 64Zn Specific activity ICP-MS Bifunctional chelators