Role of TLR1, TLR2 and TLR6 in the modulation of intestinal inflammation and lass="a-plus-plus">Candida albicans elimination

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• 作者：Laura Choteau ; Hélène Vancraeyneste ; Didier Le Roy ; Laurent Dubuquoy…
• 关键词：TLR1 ; TLR2 ; TLR6 ; Candida albicans ; E. coli ; Colitis
• 刊名：Gut Pathogens
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：9
• 期：1
• 全文大小：2246KB
• 刊物主题：Gastroenterology; Medical Microbiology; Parasitology;
• 出版者：BioMed Central
• ISSN：1757-4749
• 卷排序：9

文摘

Background Toll-like receptors (TLRs) are the major pattern recognition receptors that mediate sensing of a wide range of microorganisms. TLR2 forms heterodimers with either TLR1 or TLR6, broadening its ligand diversity against pathogens. TLR1, TLR2 and TLR6 have been implicated in the recognition of Candida albicans, an opportunistic fungal pathogen that colonizes the gastrointestinal tract. In this study, we explored whether the deficiency in TLR1, TLR2 or TLR6 impacts C. albicans colonization and inflammation-associated colonic injury in the dextran sulfate sodium (DSS)-induced colitis in mice.