Inter-organ communication and regulation of beta cell function

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• 作者：Mehboob A. Hussain ; Elina Akalestou ; Woo-jin Song
• 关键词：Beta cell ; Decretin ; Galanin ; Ghrelin ; Incretin ; Insulin ; Inter ; organ ; Islet ; Leptin ; Muscarinic ; Review ; Xenin ; 25
• 刊名：Diabetologia
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：59
• 期：4
• 页码：659-667
• 全文大小：527 KB
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• 作者单位：Mehboob A. Hussain (1) (2) (3)
  Elina Akalestou (2)
  Woo-jin Song (2)
  
  1. Department of Medicine, Johns Hopkins University, 600 N. Wolfe Street, CMSC 10-113, Baltimore, MD, 21287, USA
  2. Department of Pediatrics, Johns Hopkins University, 600 N. Wolfe Street, CMSC 10-113, Baltimore, MD, 21287, USA
  3. Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD, USA
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Metabolic Diseases
  Human Physiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0428

文摘

The physiologically predominant signal for pancreatic beta cells to secrete insulin is glucose. While circulating glucose levels and beta cell glucose metabolism regulate the amount of released insulin, additional signals emanating from other tissues and from neighbouring islet endocrine cells modulate beta cell function. To this end, each individual beta cell can be viewed as a sensor of a multitude of stimuli that are integrated to determine the extent of glucose-dependent insulin release. This review discusses recent advances in our understanding of inter-organ communications that regulate beta cell insulin release in response to elevated glucose levels.