Pediatric brain tumors in a low/middle income country: does it differ from that in developed world?

详细信息    查看全文

• 作者：Sameera Ezzat ; Mohamed Kamal ; Nada El-Khateeb…
• 关键词：CNS tumors ; Brain ; Spinal cord ; Epidemiology ; Children ; Pediatric cancer
• 刊名：Journal of Neuro-Oncology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：126
• 期：2
• 页码：371-376
• 全文大小：499 KB
• 参考文献：1.Arora RS, Alston RD, Eden TOB et al (2009) Age-incidence patterns of primary CNS tumors in children, adolescents, and adults in England. Neuro Oncol 11:403–413. doi:10.​1215/​15228517-2008-097 PubMed PubMedCentral CrossRef
  2.Orkin S (2009) Oncology of infancy and childhood. Saunders Elsevier, Philadelphia
  3.Strother DR, Pollack IF, Fisher PG, Hunter JV, Woo SY, Pomeroy SL et al (2002) Tumors of the central nervous system. In: Pizzo PA, Poplack DG (eds) Principles and practice of pediatric oncology, 4th edn. Lippincott Williams and Wilkins, New York, NY, pp 751–824
  4.Rickert CH, Paulus W (2001) Epidemiology of central nervous system tumors in childhood and adolescence based on the new WHO classification. Childs Nerv Syst 17:503–511PubMed CrossRef
  5.American Cancer Society (2012) Cancer facts and figures. American Cancer Society, Atlanta
  6.Magnani C, Aareleid T, Viscomi S et al (2001) Variation in survival of children with central nervous system (CNS) malignancies diagnosed in Europe between 1978 and 1992: the EUROCARE study. Eur J Cancer 37:711–721PubMed CrossRef
  7.Dolecek T a, Propp JM, Stroup NE, Kruchko C (2012) NEURO-ONCOLOGY CBTRUS Statistical Report: primary brain and central nervous system tumors diagnosed in the United States in 2005–2009
  8.Bleyer WA (1999) Epidemiologic impact of children with brain tumors. Child’s Nerv Syst 15:758–763. doi:10.​1007/​s003810050467 CrossRef
  9.El-Gaidi MA (2011) Descriptive epidemiology of pediatric intracranial neoplasms in Egypt. Pediatr Neurosurg 47:385–395. doi:10.​1159/​000337872 PubMed CrossRef
  10.Parkin DM (2006) The evolution of the population-based cancer registry. Nat Rev Cancer 6:603–612PubMed CrossRef
  11.Gjerris F, Agerlin N, Børgesen SE et al (1998) Epidemiology and prognosis in children treated for intracranial tumours in Denmark 1960–1984. Childs Nerv Syst 14:302–311PubMed CrossRef
  12.Bauchet L, Rigau V, Mathieu-Daudé H et al (2009) Clinical epidemiology for childhood primary central nervous system tumors. J Neurooncol 92:87–98. doi:10.​1007/​s11060-008-9740-0 PubMed CrossRef
  13.Kadri H, Mawla AA, Murad L (2005) Incidence of childhood brain tumors in Syria (1993–2002). Pediatr Neurosurg 41:173–177. doi:10.​1159/​000086557 PubMed CrossRef
  14.Harmouch A, Taleb M, Lasseini A et al (2012) Epidemiology of pediatric primary tumors of the nervous system: a retrospective study of 633 cases from a single Moroccan institution. Neurochirurgie 58:14–18. doi:10.​1016/​j.​neuchi.​2012.​01.​005 PubMed CrossRef
  15.De la Torre Mondragón L, Ridaura Sanz C, Reyes Mujica M, Rueda Franco F (1993) Central nervous system tumors in Mexican children. Childs Nerv Syst 9:260–265CrossRef
  16.Kohler BA, Ward E, McCarthy BJ et al (2011) Annual report to the nation on the status of cancer, 1975–2007, featuring tumors of the brain and other nervous system. J Natl Cancer Inst 103:714–736. doi:10.​1093/​jnci/​djr077 PubMed PubMedCentral CrossRef
  17.Beygi S, Saadat S, Jazayeri SB, Rahimi-Movaghar V (2013) Epidemiology of pediatric primary malignant central nervous system tumors in Iran: a 10 year report of National Cancer Registry. Cancer Epidemiol. doi:10.​1016/​j.​canep.​2013.​03.​002 PubMed
  18.Mehrvar A, Faranoush M, Hedayati Asl AA et al (2014) Childhood central nervous system tumors at MAHAK’s Pediatric Cancer Treatment and Research Center (MPCTRC), Tehran. Iran. Childs Nerv Syst 30:491–496. doi:10.​1007/​s00381-013-2256-8 PubMed CrossRef
  19.Ibrahim AS, Khaled HM, Mikhail NNH et al (2014) Cancer incidence in Egypt : results of the population-based cancer. Regist Prog Egypt 2014:1–17
  20.Abdelbar I, Ismail K, Hablas A et al (2007) Cancer in Egypt, Gharbiah Triennial Report of 200–2002, Gharbiah
  21.Ferlay J, Shin HR, Bray F, Forman D MC and PD Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [Internet]. In: GLOBOCAN 2008 v2.0 - Lyon, Fr. Int. Agency Res. Cancer; 2010. Available from http//globocan.iarc.fr, accessed 13/8/2013
  22.Fast Stats: an interactive tool for access to SEER cancer statistics. Surveillance Research Program, National Cancer Institute. http://​seer.​cancer.​gov/​faststats . Accessed 13 Aug 2013
  23.Mehrazin M, Rahmat H, Yavari P (2006) Epidemiology of primary intracranial tumors in Iran, 1978–2003. Asian Pac J Cancer Prev 7:283–288PubMed
  24.Katchy KC, Alexander S, Al-Nashmi NM, Al-Ramadan A (2013) Epidemiology of primary brain tumors in childhood and adolescence in Kuwait. Springerplus 2:58. doi:10.​1186/​2193-1801-2-58 PubMed PubMedCentral CrossRef
  
• 作者单位：Sameera Ezzat (1)
  Mohamed Kamal (2)
  Nada El-Khateeb (2)
  Mohamed El-Beltagy (3)
  Hala Taha (4)
  Amal Refaat (5)
  Madeha Awad (6)
  Sherif Abouelnaga (6)
  Mohamed Saad Zaghloul (7)
  
  1. National Liver Institute, Menoufia University, Al Minufya, Egypt
  2. Research Department, Children’s Cancer Hospital Egypt (CCHE) and National Cancer Institute, Cairo University, 1 Sekket El Emmam, Sayeda Zainab, Cairo, Egypt
  3. Neurosurgery Department, Cairo University, 1 Sekket El Emmam, Sayeda Zainab, Cairo, Egypt
  4. Pathology Department, Cairo University, 1 Sekket El Emmam, Sayeda Zainab, Cairo, Egypt
  5. Radiology Department, Cairo University, 1 Sekket El Emmam, Sayeda Zainab, Cairo, Egypt
  6. Pediatric Oncology Department, Cairo University, 1 Sekket El Emmam, Sayeda Zainab, Cairo, Egypt
  7. Radiotherapy Department, Children’s Cancer Hospital Egypt (CCHE) and National Cancer Institute, Cairo University, 1 Sekket El Emmam, Sayeda Zainab, Cairo, Egypt
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  
• 出版者：Springer Netherlands
• ISSN：1573-7373

文摘

Central nervous system (CNS) tumors are the most frequent solid tumors in children and adolescents. The epidemiology of these tumors differs in areas of the world. However, very little data is available in the low/middle income countries (LMIC). The aim of this study is to describe the characteristics of primary childhood brain tumors treated at a leading LMIC pediatric cancer hospital and its difference from that in other countries. One thousand one hundred fourteen children and adolescent having CNS tumors were treated in the largest pediatric cancer hospital in the Middle East during a period of 5½ years. They were diagnosed histopathologically in 80.2 %, through medical imaging in 19.4 % and via both tumor markers and imaging in the remaining 0.4 % of cases. Through epidemiological analysis was performed using all available patients’ data revealed that 96 % of the patients had primary brain tumors, while only 4 % the primary lesion was in the spinal cord. The most common histological type was astrocytic tumor (30.0 %, pilocytic (GI) = 13.2 %, GII = 10.5 % and GIII + IV (high grade) = 6.3 %) followed by embryonal tumor (23.2 %, medulloblastoma = 18.7 %, PNET = 2.8 %, ATRT = 1.5 % and ependymoblastoma = 0.2 %) then ependymoma in 8.7 %, craniopharyngeoma in 5.3 %. The mean age at diagnosis was 7.1 ± 4.2 years which did not differ significantly by gender nor residency but it differed by the pathological subtype. The frequency of each pathological type was different among different age groups. Though the present study was a hospital-based analysis in a low/middle income country, yet it did not differ from the well-established population-based study reports in the high income countries.