Comparison of automated brain volumetry methods with stereology in children aged 2 to 3 years

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• 作者：Kristina N. Mayer ; Beatrice Latal ; Walter Knirsch ; Ianina Scheer…
• 关键词：MRI ; Brain segmentation ; Brain volume ; Children ; Congenital heart disease
• 刊名：Neuroradiology
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：58
• 期：9
• 页码：901-910
• 全文大小：1,136 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Neuroradiology
  Imaging and Radiology
  Neurology
  Neurosurgery
  Neurosciences
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1920
• 卷排序：58

文摘

IntroductionThe accurate and precise measurement of brain volumes in young children is important for early identification of children with reduced brain volumes and an increased risk for neurodevelopmental impairment. Brain volumes can be measured from cerebral MRI (cMRI), but most neuroimaging tools used for cerebral segmentation and volumetry were developed for use in adults and have not been validated in infants or young children. Here, we investigate the feasibility and accuracy of three automated software methods (i.e., SPM, FSL, and FreeSurfer) for brain volumetry in young children and compare the measures with corresponding volumes obtained using the Cavalieri method of modern design stereology.