Using Dual Fluorescence Reporting Genes to Establish an In Vivo Imaging Model of Orthotopic Lung Adenocarcinoma in Mice

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• 作者：Cheng-Wei Lai ; Hsiao-Ling Chen ; Chih-Ching Yen…
• 关键词：Key wordsNSCLC ; Near ; infrared fluorescence ; iRFP ; Orthotopic xenograft ; Live imaging
• 刊名：Molecular Imaging and Biology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：18
• 期：6
• 页码：849-859
• 全文大小：8,376 KB
• 刊物主题：Imaging / Radiology;
• 出版者：Springer US
• ISSN：1860-2002
• 卷排序：18

文摘

PurposeLung adenocarcinoma is characterized by a poor prognosis and high mortality worldwide. In this study, we purposed to use the live imaging techniques and a reporter gene that generates highly penetrative near-infrared (NIR) fluorescence to establish a preclinical animal model that allows in vivo monitoring of lung cancer development and provides a non-invasive tool for the research on lung cancer pathogenesis and therapeutic efficacy.