Upper gastrointestinal complications associated with gemcitabine-concurrent proton radiotherapy for inoperable pancreatic cancer

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• 作者：Kento Takatori (1)
  Kazuki Terashima (3)
  Rihito Yoshida (1)
  Aya Horai (1)
  Shinya Satake (1)
  Takayuki Ose (1)
  Naoto Kitajima (1)
  Yoshikazu Kinoshita (2)
  Yusuke Demizu (3)
  Nobukazu Fuwa (3)
  
• 关键词：Proton radiotherapy ; Pancreatic cancer ; Radiation ulcer
• 刊名：Journal of Gastroenterology
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：49
• 期：6
• 页码：1074-1080
• 全文大小：
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• 作者单位：Kento Takatori (1)
  Kazuki Terashima (3)
  Rihito Yoshida (1)
  Aya Horai (1)
  Shinya Satake (1)
  Takayuki Ose (1)
  Naoto Kitajima (1)
  Yoshikazu Kinoshita (2)
  Yusuke Demizu (3)
  Nobukazu Fuwa (3)
  
  1. Department of Internal Medicine, Kasai City Hospital, 1-13 Yokoo, Houjou, Kasai, Hyogo, 675-2393, Japan
  3. Department of Radiology, Hyogo Ion Beam Medical Center, Shingu, Hyogo, Japan
  2. Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Izumo, Shimane, Japan
  
• ISSN：1435-5922

文摘

Background Little is known about acute upper gastrointestinal (GI) complications associated with gemcitabine-concurrent proton radiotherapy (GPT) for inoperable pancreatic cancer. We investigated acute GI complications following GPT in patients with inoperable pancreatic cancer using small-bowel endoscopy. Methods This prospective single center observational study was conducted at the Hyogo Ion Beam Medical Center from January 2010 to January 2012. Ninety-one patients who had clinically and medically inoperable pancreatic cancer treated by GPT were analyzed. Endoscopic examinations were performed before and after GPT to clarify the incidence rates of radiation-induced ulcers, GI hemorrhage, and GI perforation associated with GPT. Results Post-treatment endoscopic examinations revealed that 45 (49.4?%) patients had radiation-induced ulcers in the stomach and duodenum. Of those, many ulcerative lesions were found in the lower stomach (51?%) and horizontal part of the duodenum (39?%), regardless of the primary tumor site in the pancreas. Neither GI hemorrhage, nor perforation, was found in post-treatment endoscopy examinations. Conclusion Approximately half of the patients treated with GPT for inoperable pancreatic cancer exhibited radiation-induced ulcers in the stomach and duodenum.