Impacts of age on coronary atherosclerosis and vascular response to statin therapy

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• 作者：Tsuyoshi Nozue (1)
  Shingo Yamamoto (2)
  Shinichi Tohyama (3)
  Kazuki Fukui (4)
  Shigeo Umezawa (5)
  Yuko Onishi (5)
  Tomoyuki Kunishima (6)
  Akira Sato (7)
  Toshihiro Nozato (8)
  Shogo Miyake (9)
  Youichi Takeyama (10)
  Yoshihiro Morino (11)
  Takao Yamauchi (12)
  Toshiya Muramatsu (13)
  Tsutomu Hirano (14)
  Kiyoshi Hibi (15)
  Mitsuyasu Terashima (16)
  Ichiro Michishita (1)
  
• 关键词：Age ; Atherosclerosis ; Coronary artery disease ; Statin ; Virtual histology intravascular ultrasound
• 刊名：Heart and Vessels
• 出版年：2014
• 出版时间：July 2014
• 年：2014
• 卷：29
• 期：4
• 页码：456-463
• 全文大小：208 KB
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• 作者单位：Tsuyoshi Nozue (1)
  Shingo Yamamoto (2)
  Shinichi Tohyama (3)
  Kazuki Fukui (4)
  Shigeo Umezawa (5)
  Yuko Onishi (5)
  Tomoyuki Kunishima (6)
  Akira Sato (7)
  Toshihiro Nozato (8)
  Shogo Miyake (9)
  Youichi Takeyama (10)
  Yoshihiro Morino (11)
  Takao Yamauchi (12)
  Toshiya Muramatsu (13)
  Tsutomu Hirano (14)
  Kiyoshi Hibi (15)
  Mitsuyasu Terashima (16)
  Ichiro Michishita (1)
  
  1. Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel Mutual Associations, 132 Katsura-cho, Sakae-ku, Yokohama, 247-8581, Japan
  2. Department of Cardiology, Tsurumi Nishiguchi Hospital, Yokohama, Japan
  3. Department of Cardiology, Yokohama Seamen’s Insurance Hospital, Yokohama, Japan
  4. Department of Cardiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan
  5. Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan
  6. Fourth Department of Internal Medicine, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki, Japan
  7. Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Japan
  8. Department of Cardiology, National Hospital Organization, Disaster Medical Center, Tokyo, Japan
  9. Department of Cardiology, Ebina General Hospital, Ebina, Japan
  10. Division of Cardiology, Showa University Fujigaoka Rehabilitation Hospital, Yokohama, Japan
  11. Department of Cardiology, Tokai University School of Medicine, Isehara, Japan
  12. Department of Cardiology, Tokyo Women’s Medical University, Tokyo, Japan
  13. Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan
  14. First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
  15. Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan
  16. Cardiovascular Imaging Center, Toyohashi, Japan
  
• ISSN：1615-2573

文摘

Age is a well-established risk factor for cardiovascular disease. Recent trials using intravascular ultrasound (IVUS) have shown that lipid-lowering therapy with statins halts the progression or induces the regression of coronary artery plaques. However, impacts of age on coronary atherosclerosis and vascular response to statin therapy have not been fully evaluated. The effects of 8-month statin therapy on coronary atherosclerosis were evaluated using virtual histology-IVUS. IVUS data were analyzed from 119 patients who were divided into two groups according to age: elderly patients (?5?years, n?=?72) and non-elderly patients (n?=?47). No patients were taking statins or other lipid-lowering therapies at baseline. At baseline, external elastic membrane (EEM) volume (17.27 vs. 14.95?mm3/mm, p?=?0.02) and plaque volume (9.49 vs. 8.11?mm3/mm, p?=?0.03) in the elderly patients were significantly greater than in the non-elderly patients. The EEM volume (?.4?%, p?=?0.007) and plaque volume (?.1?%, p?=?0.007) after 8-month of statin therapy had significantly decreased in the non-elderly patients but not in the elderly patients. A significant positive correlation was observed between age and percentage change in plaque volume (r?=?0.265, p?=?0.004). A multivariate regression analysis showed that age was a significant predictor of the percentage change in plaque volume during statin therapy (β?=?0.223, p?=?0.02). Coronary atherosclerosis was more advanced and vascular responses to statin therapy were attenuated in the elderly patients compared to the non-elderly patients.