The exocyst in Candida albicans polarized secretion and filamentation

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• 作者：Alba A. Chavez-Dozal ; Stella M. Bernardo ; Samuel A. Lee
• 关键词：Exocyst ; Filamentation ; Polarisome ; SEC6 ; SEC15 ; Secretion ; Spitzenkörper
• 刊名：Current Genetics
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：62
• 期：2
• 页码：343-346
• 全文大小：887 KB
• 参考文献：Bernardo SM, Rane HS, Chavez-Dozal A, Lee SA (2014) Secretion and filamentation are mediated by Candida albicans t-SNAREs Sso2 p and Sec9p. FEMS Yeast Res. doi:10.​1111/​1567-1364.​12165 PubMed PubMedCentral
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• 作者单位：Alba A. Chavez-Dozal (1) (2)
  Stella M. Bernardo (1) (2)
  Samuel A. Lee (1) (2)
  
  1. Section of Infectious Diseases, New Mexico VA Healthcare System, 1501 San Pedro SE, Mail Code 111-J, Albuquerque, NM, 87108, USA
  2. Division of Infectious Diseases, University of New Mexico Health Science Center, Albuquerque, NM, 87131, USA
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Microbial Genetics and Genomics
  Microbiology
  Biochemistry
  Cell Biology
  Plant Sciences
  Proteomics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0983

文摘

The exocyst is an octameric complex that orchestrates the docking and tethering of vesicles to the plasma membrane during exocytosis and is fundamental for key biological processes including growth and establishment of cell polarity. Although components of the exocyst are well conserved among fungi, the specific functions of each component of the exocyst complex unique to Candida albicans biology and pathogenesis are not fully understood. This commentary describes recent findings regarding the role of exocyst subunits Sec6 and Sec15 in C. albicans filamentation and virulence.