Parathyroid adenoma detected with 99mTc-tetrofosmin dual-phase scintigraphy: a case report

详细信息    查看全文

• 作者：Konstantinos Romanidis ; Evangelos Karathanos…
• 关键词：Parathyroid adenoma ; 99mTc ; tetrofosmin dual ; phase scintigraphy ; p ; glycoprotein ; Nuclear medicine ; Parathormone ; Parathyroidectomy
• 刊名：BMC Research Notes
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：7
• 期：1
• 全文大小：460 KB
• 参考文献：1. Xu, SY, Wang, Y, Xie, Q, Wu, HY (2013) Percutaneous sonographically-guided radiofrequency ablation in the management of parathyroid adenoma. Singapore Med J 9: pp. 1-10
  2. Nasiri, S, Soroush, A, Hashemi, AP, Hedayat, A, Donboli, K, Mehrkhani, F (2012) Parathyroid adenoma Localization. Med J Islam Repub Iran 26: pp. 103-109 CrossRef
  3. Lind, P (1997) Parathyroid imaging with technetium- 99?m labeled cationic complexes: which tracer and which technique should be used?. Eur J Nucl Med 24: pp. 243-245 CrossRef
  4. Giordano, A, Meduri, G, Marozzi, P (1996) Parathyroid imaging with Tc-99?m tetrofosmin. Nucl Med Commun 17: pp. 706-710 CrossRef
  5. Palestro, CJ, Tomas, MB, Tronco, GG (2005) Radionuclide imaging of the parathyroid glands. Semin Nucl Med 35: pp. 266-276 CrossRef
  6. Mitchell, BK, Cornelius, EA, Zoghbi, S, Murren, JR, Ghoussoub, R, Flynn, SD, Kinder, BK (1996) Mechanism of technetium 99?m sestamibi parathyroid imaging and the possible role of p-glycoprotein. Surgery 120: pp. 1039-1045 CrossRef
  7. Mellou, M, Paz, A, Koren, R, Cytron, S, Feinmesser, R, Gal, R (2001) 99mTc- MIBI scintigraphy of parathyroid adenomas and its relation to tumor size and oxyphil cell abundance. Eur J Nucl Med 28: pp. 209-213 CrossRef
  8. Aigner, RM, Füger, GF, Nicoletti, R (1996) Parathyroid scintigraphy: comparison of technetium -99?m methoxyisobutilisonitrile and technetium 99?m tetrofosmin studies. Eur J Nucl Med 23: pp. 693-696 CrossRef
  9. Athanasoulis, D, Anagnostopoulos, Z, Vezirgianni, A (1996) Comparison of technetium-99?m sestamibi and technetium-99?m tetrofosmin in parathyroid scintigraphy. Eur J Nucl Med 23: pp. 1169
  10. Chiu, ML, Kronauge, JF, Piwnica, WD (1990) Effect of mitochondrial and plasma membrane potential on accumulation of Hexakis (2-Methoxy isobutyl isonitrile) Technetium in cultured mouse fibroblasts. J Nucl Med 31: pp. 1646-1653 CrossRef
  11. Taillefer, R, Boucher, Y, Potvin, C, Lambert, R (1992) Detection and localization of parathyroid adenomas in patients with hyperparathyroidism using a single radionuclide imaging procedure with technetium-99?m-sestamibi (double phase study). J Nucl Med 33: pp. 1801-1807 CrossRef
  12. Bhatnagar, A, Vezza, PR, Bryan, JA, Atkins, FB, Ziessman, HA (1998) Technetium-99?m-sestamibi. parathyroid scintigraphy: effect of P-glycoprotein, histology and tumor size on detectability. J Nucl Med 39: pp. 1617-1620 CrossRef
  13. Kao, A, Shiau, YC, Tsai, SC, Wang, JJ, Ho, ST (2002) Technetium-99?m methoxyisobutylisonitrile imaging for parathyroid adenoma: relationship to P-glycoprotein or multidrug resistance-related protein expression. Eur J Nucl Med 29: pp. 1012-1015 CrossRef
  14. Sun, SS, Shiau, YC, Lin, CC, Kao, A, Lee, CC (2001) Correlation between P-glycoprotein (P-gp) expression in parathyroid and Tc-99?m MIBI parathyroid image findings. Nucl Med Biol 28: pp. 929-933 CrossRef
  15. Wu, HS, Liu, YC, Kao, A, Wang, JJ, Ho, ST (2002) Using technetium 99?m tetrofosmin parathyroid imaging to detect parathyroid adenoma and its relation to P-glycoprotein expression. Surgery 132: pp. 456-460 CrossRef
  
• 刊物主题：Biomedicine general; Medicine/Public Health, general; Life Sciences, general;
• 出版者：BioMed Central
• ISSN：1756-0500

文摘

Background Tc-sestamibi is the most frequently used radionuclide agent for the detection of parathyroid adenomas in the clinical setting. However, Tc-tetrofosmin is another such agent that may be used for this purpose. This case report presents the significance and practicality of 99mTc-tetrofosmin for the diagnosis of parathyroid adenomas with probable high p-glycoprotein levels. Case presentation A 45-year-old woman was referred to our Nuclear Department with a palpable neck nodule suspicious for parathyroid adenoma. She had no significant medical history or other accompanying symptoms. Blood examination results were normal with the exception of the parathormone level which was high at 167.2?pg/ml. Neck ultrasonography revealed a hypoechoic mass near the lower pole of the thyroid gland. 99m Tc-tetrofosmin dual-phase scintigraphy with early and delayed images was performed and the results supported the presupposition of parathyroid adenoma as shown by increased radiopharmaceutical levels near the lower left thyroid gland on the early image that disappeared on the delayed image. Moreover, TcO4 ?/sup> thyroid scintigraphy results excluded thyroid pathology. Two months after the diagnosis, parathyroidectomy was successfully performed without postoperative complications. The pathology report and clinical response to a gradual decrease of parathormone confirmed the initial diagnosis. Conclusion We strongly recommend the use of reverse 99m Tc-tetrofosmin scintigraphy as a useful and safe examination technique for the diagnosis of parathyroid adenomas.