Increased immunoexpression of trefoil factors in salivary gland tumors

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• 作者：Ponlatham Chaiyarit (1) (2)
  Poramaporn Klanrit (1) (2)
  Pensri Photipakdee (1) (2)
  Ajiravudh Subarnbhesaj (1) (2)
  Andrew S. Giraud (3)
  
• 关键词：Immunohistochemistry ; Salivary gland tumor ; Trefoil factor
• 刊名：Clinical Oral Investigations
• 出版年：2014
• 出版时间：May 2014
• 年：2014
• 卷：18
• 期：4
• 页码：1305-1312
• 全文大小：
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• 作者单位：Ponlatham Chaiyarit (1) (2)
  Poramaporn Klanrit (1) (2)
  Pensri Photipakdee (1) (2)
  Ajiravudh Subarnbhesaj (1) (2)
  Andrew S. Giraud (3)
  
  1. Department of Oral Diagnosis, Faculty of Dentistry, Khon Kaen University, Khon Kaen, 40002, Thailand
  2. Research group of chronic inflammatory oral diseases and systemic diseases associated with oral health, Khon Kaen University, Khon Kaen, 40002, Thailand
  3. Murdoch Childrens Research Institute, The Royal Children’s Hospital, Flemington Road Parkville, Melbourne, VIC, 3052, Australia
  
• ISSN：1436-3771

文摘

Objective Very little is known about the role of trefoil factors (TFFs) in salivary gland tumors, and TFF immunoexpression has never been investigated in such tumors. The aim of this study was to evaluate TFF immunoexpression in benign and malignant salivary gland tumors. Materials and methods Benign (n--5) and malignant (n--5) salivary gland tumor specimens were included in this study, using mucocele (n--5) specimens as a control group. Immunohistochemical staining was performed to evaluate the expression of TFFs (TFF1, TFF2, and TFF3) by semiquantitative means. Results Expression of TFF1, TFF2, and TFF3 was significantly increased in benign (p--.001, p--.005, p-lt;-.001, respectively) and malignant (p-lt;-.001, p-lt;-.001, p-lt;-.001, respectively) groups as compared with the control group. Patterns of co-expression between TFF1/TFF2, TFF2/TFF3, and TFF1/TFF3 were different among the three groups. Conclusions The present study provided new information showing that all TFFs were significantly increased in benign and malignant salivary gland tumors, and overexpression of TFFs could be associated with neoplastic transformation in salivary gland tissues. Clinical relevance Overexpression of TFFs may be useful as biomarkers in terms of differential diagnosis between salivary gland tumors and other oral neoplasms for which clinical manifestations are indistinguishable.