Fatal rhinocerebral mucormycosis with intracavernous carotid aneurysm and thrombosis: a late complication of transsphenoidal surgery?

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• 作者：Anne Dusart (1)
  Thierry Duprez (2)
  Sylvie Van Snick (3)
  Catherine Godfraind (4)
  Christian Sindic (1)
  
• 关键词：Rhinocerebral mucormycosis ; Carotid aneurysm ; Mucorthrombosis ; Transsphenoidal surgery
• 刊名：Acta Neurologica Belgica
• 出版年：2013
• 出版时间：June 2013
• 年：2013
• 卷：113
• 期：2
• 页码：179-184
• 全文大小：592KB
• 参考文献：1. Spellberg B, Edwards J Jr, Ibrahim A (2005) Novel perspectives on mucormycosis: pathophysiology, presentation, and management. Clin Microbiol Rev 18:556-59 CrossRef
  2. Antachopoulos C, Gea-Banacloche J, Walsh T (2008) Zygomycosis (mucormycosis). In: Hospenthal D, Rinaldi M (eds) Diagnosis and treatment of human mycoses (infectious disease). Humana Press, Totowa, pp 227-43 CrossRef
  3. Prabhu R, Patel R (2004) Mucormycosis and entomophthoramycosis: a review of the clinical manifestations, diagnosis and treatment. Clin Microbiol Infect 10(Suppl 1):31-7 CrossRef
  4. Sundaram C, Mahadevan A, Laxmi V, Yasha TC, Santosh V, Murthy J, Purohit A, Mohandas S, Shankar S (2005) Cerebral zygomycosis. Mycoses 48:396-07 CrossRef
  5. Christoff J, Galaydick JL, Ramaprasad C, Pitrak D, Mullane K (2010) Current diagnosis and management of mucormycoses. Curr Fungal Infect Rep 4:8-6 CrossRef
  6. Thajeb P, Thajeb T, Dai D (2004) Fatal strokes in patients with rhino-orbito-cerebral mucormycosis and associated vasculopathy. Scand J Infect Dis 36:643-48 CrossRef
  7. Mallis A, Mastronikolis S, Naxakis S, Papadas A (2010) Rhinocerebral mucormycosis: an update. Eur Rev Med Pharmacol Sci 14:987-92
  8. Anand V, Alemar G, Griswold J (1992) Intracranial complications of mucormycosis: an experimental model and clinical review. Laryngoscope 102:656-62 CrossRef
  9. Gl?kner A, Vehreschild JJ, Cornely OA (2007) Zygomycosis—current epidemiological aspects. Mycoses 50(Suppl 1):50-5 CrossRef
  10. Roden M, Zaoutis E, Buchanan W et al (2005) Epidemiology and outcomes of zygomycosis: a review of 929 reported cases. Clin Inf Dis 41:634-53 CrossRef
  11. Mohindra S, Mohindra S, Gupta R, Bakshi J, Gupta S (2007) Rhinocerebral mucormycosis: the disease spectrum in 27 patients. Mycoses 50:290-96 CrossRef
  12. Elinav H, Zimhony O, Cohen M, Marcovich A, Benenson S (2009) Rhinocerebral mucormycosis in patients without predisposing medical conditions: a review of the literature. Clin Microbiol Infection 15:693-97 CrossRef
  13. Eucker J, Sezer O, Graf B, Possinger K (2001) Mucormycoses. Mycoses 44:253-60 CrossRef
  14. Murthy J (2007) Fungal infections of the central nervous system: the clinical syndromes. Neurol India 55:221-25 CrossRef
  15. Yohai R, Bullock J, Aziz A, Markert R (1994) Survival factors in rhino-orbital-cerebral mucormycosis. Surv Ophthalmol 39:3-2 CrossRef
  16. Chopra H, Dua K, Malhotra V, Gupta R, Pruri H (2005) Invasive fungal sinusitis of isolated sphenoid sinus in immunocompetent subjects. Mycoses 49:30-6 CrossRef
  17. Bansal S, Grover G, Grover M, Gupta AK (2010) Isolated spheno?d mucormycosis presenting as visual impairment: changing trends ? Am J Otolaryngol 31:64-6 CrossRef
  18. Alleyne C, Vishted A, Giancarlo A, Spetzler R, Detwiler P (1999) Long-term survival of a patient with invasive cranial base rhinocerebral mucormycosis treated with combined endovascular, surgical and medical therapies: case report. Neurosurgery 45:1461-464 CrossRef
  19. Anaissie E, Shikhani A (1985) Rhinocerebral mucormycosis with internal carotid occlusion: report of two cases and review of the literature. Laryngoscope 95:1107-113 CrossRef
  20. Harrill W, Stewart M, Lee A, Cernoch P (1996) Chronic rhinocerebral mucormycosis. Laryngoscope 106:1292-297 CrossRef
  21. Ericsson M, Anniko M, Gustafsson H, Hjalt CA, Stenling R, T?rnvik A (1993) A case of chronic progressive rhinocerebral mucormycosis treated with liposomal amphotericin B and surgery. Clin Inf Dis 16:585-86 CrossRef
  22. Galetta S, Wulc A, Goldberg H, Nichols C, Glaser J (1990) Rhinocerebral mucormycosis: management and survival after carotid occlusion. Ann Neurol 28:103-07 CrossRef
  23. Hashemzadeh S, Tubbs R, Fakhree M, Shoja M (2008) Mucormycotic pseudoaneurysm of the common carotid artery with tracheal involvement. Mycoses 51:347-51 CrossRef
  24. Hurst R, Jundkins A, Bolger W, Chu A, Loevner L (2001) Mycotic aneurysm and cerebral infarction resulting from fungal sinusitis: imaging and pathologic correlation. Am J Neuroradiol 22:858-63
  25. Mielke B, Weir B, Oldring D, von Westarp C (1981) Fungal aneurysm: case report and review of the literature. Neurosurgery 9:578-82 CrossRef
  26. Alvernia J, Patel R, Cai D, Dang N, Anderson D, Melgar M (2009) A successful combined endovascular and surgical treatment of a cranial base mucormycosis with associated internal carotid artery pseudoaneurysm. Neurosurgery 65:733-40 CrossRef
  27. Kasliwal M, Reddy V, Sinha S, Sharma B, Das P, Suri V (2009) Bilateral anterior cerebral artery aneurysm due to mucormycosis. J Clin Neurosci 16:156-59 CrossRef
  
• 作者单位：Anne Dusart (1)
  Thierry Duprez (2)
  Sylvie Van Snick (3)
  Catherine Godfraind (4)
  Christian Sindic (1)
  
  1. Service de Neurologie, Cliniques universitaires Saint-Luc, Université Catholique de Louvain, Avenue Hippocrate, 10, 1200, Bruxelles, Belgium
  2. Département d’Imagerie Médicale, Cliniques universitaires Saint-Luc, Université Catholique de Louvain, Avenue Hippocrate, 10, 1200, Bruxelles, Belgium
  3. Service de Neurologie, Cliniques Saint-Joseph, 4000, Liège, Belgium
  4. Laboratoire de Neuropathologie, Cliniques universitaires Saint-Luc, Université Catholique de Louvain, Avenue Hippocrate, 10, 1200, Bruxelles, Belgium
  
• ISSN：2240-2993

文摘

Mucormycosis is a rare opportunistic fungal infection. Rhinocerebral form of the disease mainly affects diabetic or immunocompromised patients. Mucormycosis have specific tropism for blood vessels leading to mucorthrombosis and less often to mycotic aneurysms. We report on a patient initially presenting with a severe sphenoid sinusopathy, who progressively evolved to cavernous sinus syndrome, internal carotid aneurysm followed by spontaneous thrombosis, chronic meningitis and ultimately fatal hypertensive hydrocephalus. Necropsy revealed a purulent infiltrate containing thin-walled, aseptate, right-angle branching, hyphae consistent with mucormycosis. His only relevant previous medical history was a transsphenoidal surgery for pituitary macroadenoma 21?years before. We hypothesize that post-surgical mucosal changes in the sphenoid sinus have been a favoring factor for delayed and invasive mucor infection.