Xenon computed tomography can evaluate the improvement of hepatic hemodynamics before and after endoscopic injection sclerotherapy

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• 作者：Hideaki Takahashi (1) (3)
  Michihiro Suzuki (1)
  Ryuta Shigefuku (1)
  Miki Okano (1)
  Tetsuya Hiraishi (1)
  Rei Takagi (1)
  Yohei Noguchi (1)
  Nobuhiro Hattori (1)
  Moriaki Hatsugai (1)
  Kazunari Nakahara (1)
  Masaru Okamoto (1)
  Minoru Kobayashi (1)
  Hiroki Ikeda (1)
  Yasunobu Fukuda (1)
  Yoshihiko Nagase (1)
  Toshiya Ishii (1)
  Kotaro Matsunaga (1)
  Nobuyuki Matsumoto (1)
  Chiaki Okuse (1)
  Shigeru Sase (2)
  Fumio Itoh (1)
  
• 关键词：Xe computed tomography ; Portal hypertension ; Hepatic tissue blood flow ; Sclerotherapy
• 刊名：Journal of Gastroenterology
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：48
• 期：12
• 页码：1353-1361
• 全文大小：
• 作者单位：Hideaki Takahashi (1) (3)
  Michihiro Suzuki (1)
  Ryuta Shigefuku (1)
  Miki Okano (1)
  Tetsuya Hiraishi (1)
  Rei Takagi (1)
  Yohei Noguchi (1)
  Nobuhiro Hattori (1)
  Moriaki Hatsugai (1)
  Kazunari Nakahara (1)
  Masaru Okamoto (1)
  Minoru Kobayashi (1)
  Hiroki Ikeda (1)
  Yasunobu Fukuda (1)
  Yoshihiko Nagase (1)
  Toshiya Ishii (1)
  Kotaro Matsunaga (1)
  Nobuyuki Matsumoto (1)
  Chiaki Okuse (1)
  Shigeru Sase (2)
  Fumio Itoh (1)
  
  1. Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao Miyamae-ku, Kawasaki, Kanagawa, 216-8511, Japan
  3. Division of Gastroenterology, Department of Internal Medicine, Sapporo Shirakabadai Hospital, Sapporo, Japan
  2. Anzai Medical Company, Ltd, Tokyo, Japan
  
• ISSN：1435-5922

文摘

Background Xenon computed tomography (Xe-CT) provides quantitative information on tissue blood flow (TBF). In the present study, Xe-CT was performed in patients with esophagogastric varices (EGV) before and after endoscopic injection sclerotherapy (EIS) to evaluate hepatic blood flow (HBF), hepatic arterial TBF (HATBF) and portal venous TBF (PVTBF). Methods Subjects comprised of 88 patients with EGV (49 men, 39 women, average age 65.811.5years, median age 68years, 306years) and liver cirrhosis related to either hepatitis C virus (C) (n=33), hepatitis B virus (B) (n=3), alcohol (AL) (n=22), AL+C (n=7), AL+B (n=1), B+C+AL (n=1), nonalcoholic steatohepatitis (NASH) (n=4), autoimmune hepatitis (AIH) (n=5), primary biliary cirrhosis (PBC) (n=2), or cryptogenic (n=10) were enrolled. All patients, who were enrolled in this study, were performed EIS for prophylaxis. Xe-CT and measurement of the retention rate of indocyanine green 15min after administration (ICG R15) were performed before and after EIS. Total hepatic TBF (THTBF) and PVTBF/HATBF ratio (P/A) were also calculated. Results PVTBF, HATBF, THTBF, P/A and ICG R15 before EIS were 28.38.91, 22.514.4 and 50.817.6ml/100ml/min, 1.620.71 and 28.812.7%, respectively and those after EIS were 31.910.0, 19.311.6, and 51.217.0ml/100ml/min, 1.920.84 and 23.611.3%, respectively. PVTBF and P/A after EIS were significantly higher than those before EIS (p=0.00444, p=0.0179, respectively), and HATBF and ICG R15 after EIS were significantly lower than those before EIS (p=0.00129, p<0.001, respectively). Conclusions Xenon computed tomography showed that PVTBF increased after EIS for EGV and HATBF decreased in response to an increase in PVTBF.