Thymus activity measured by T-cell receptor excision circles in patients with different severities of respiratory syncytial virus infection

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• 作者：Kiran Aftab Gul ; Tonje Sonerud ; Hans O. Fjærli ; Britt Nakstad…
• 关键词：Respiratory syncytial virus ; Thymus ; T ; cell receptor excision circles ; Children ; Bronchiolitis
• 刊名：BMC Infectious Diseases
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：17
• 期：1
• 全文大小：489KB
• 刊物主题：Infectious Diseases; Parasitology; Medical Microbiology; Tropical Medicine; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2334
• 卷排序：17

文摘

BackgroundRespiratory syncytial virus (RSV) infection is an important cause of hospitalization in previously healthy infants. Immunological mechanisms predisposing infants to severe disease are poorly understood. Early biomarkers for disease severity may assist clinical decisions. We investigated T-cell receptor excision circles (TREC), episomal DNA made during thymic T-cell receptor rearrangement, and a marker for thymus activity, both during disease and in neonatal screening cards as a risk factor for RSV disease severity.