Contrasting the Influence of Cationic Amino Acids on the Viscosity and Stability of a Highly Concentrated Monoclonal Antibody

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• 作者：Barton J. Dear ; Jessica J. Hung ; Thomas M. Truskett&#8230
• 关键词：KEY WORDSantibody ; arginine ; histidine ; rheology ; viscosity
• 刊名：Pharmaceutical Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：34
• 期：1
• 页码：193-207
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Pharmacology/Toxicology; Pharmacy; Biochemistry, general; Medical Law; Biomedical Engineering;
• 出版者：Springer US
• ISSN：1573-904X
• 卷排序：34

文摘

PurposeTo explain the effects of cationic amino acids and other co-solutes on the viscosity, stability and protein-protein interactions (PPI) of highly concentrated (≥200 mg/ml) monoclonal antibody (mAb) solutions to advance subcutaneous injection.