Phytochemical composition, protective and therapeutic effect on gastric ulcer and α-amylase inhibitory activity of Achillea biebersteinii Afan.

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• 作者：Howaida I. Abd-Alla ; Nagwa M. M. Shalaby ; Manal A. Hamed…
• 关键词：Achillea biebersteinii ; Germacranolides ; Guaianolides ; 3 ; Methoxy flavones ; Gastric ulcer ; α ; Amylase inhibition
• 刊名：Archives of Pharmacal Research
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：39
• 期：1
• 页码：10-20
• 全文大小：1,857 KB
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• 作者单位：Howaida I. Abd-Alla (1)
  Nagwa M. M. Shalaby (1)
  Manal A. Hamed (2)
  Nagy Saba El-Rigal (2)
  Samira N. Al-Ghamdi (3)
  Jalloul Bouajila (4)
  
  1. Department of Natural Compounds Chemistry, National Research Centre, Dokki, 12622, Giza, Egypt
  2. Department of Therapeutic Chemistry, National Research Centre, Dokki, 12622, Giza, Egypt
  3. Faculty of Science, Branch of Girls, King Abdul-Aziz University, 21589, Jeddah, Saudi Arabia
  4. Université de Toulouse, Faculté de pharmacie de Toulouse, Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique UMR CNRS 5623, Université Paul-Sabatier, 118 route de Narbonne, 31062, Toulouse, France
  
• 刊物主题：Pharmacy; Pharmacology/Toxicology;
• 出版者：Springer Netherlands
• ISSN：1976-3786

文摘

Three sesquiterpene lactones [two germacranolides (micranthin and sintenin) and one guaianolide (4β,10α-dihydroxy-5β,7β,8βH-guaia-1,11(13)dien-12,8α-olide)] and four derivatives of 3-methoxy flavones (santin, quercetagetin-3,6,3′-trimethyl ether, quercetagetin-3,6-dimethyl ether, and 5,7 dihydroxy 3,3′,4′-trimethoxy flavone) were isolated from the ethyl acetate extract (EAE) of the aerial parts of Achillea biebersteinii Afan. (Asteraceae). Evaluation of protective and therapeutic effects of EAE against ethanol-induced gastric ulcer in rats was carried. Antiulcer activity evaluation was done through measuring ulcer indices, stomach acidity, gastric volume and lesion counts. Oxidative stress markers; malondialdehyde, glutathione and superoxide dismutase were also estimated. The work was extended to determine the histopathological assessment of the stomach. Gastric ulcer exhibited a significant elevation of the ulcer index and oxidative stress markers. The extract attenuated these increments and recorded protective and therapeutic effects against gastric ulcer. Hyperglycaemia increases the mucosal susceptibility to ulcerogenic stimuli and predisposes gastric ulceration. In vitro α-amylase inhibitory assay was applied to evaluate the post prandial antihyperglycaemia activity. The result showing that the EAE has the ability to reduce starch-induced postprandial glycaemic excursions by virtue of potent intestinal α-amylase inhibitory activity. These findings demonstrated the remarkable potential of A. biebersteinii as valuable source of antiulcer agent with post prandial hyperglycaemia lowering effect. Keywords Achillea biebersteinii Germacranolides Guaianolides 3-Methoxy flavones Gastric ulcer α-Amylase inhibition