Molecular profile of urothelial carcinoma of the upper urinary tract: are pelvicalyceal and ureteral tumors different?

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• 作者：Laura-Maria Krabbe ; Aditya Bagrodia ; Mary E. Westerman…
• 关键词：Comparison ; Molecular markers ; Upper urinary tract ; Urothelial carcinoma
• 刊名：World Journal of Urology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：34
• 期：1
• 页码：105-112
• 全文大小：637 KB
• 参考文献：1.Munoz JJ, Ellison LM (2000) Upper tract urothelial neoplasms: incidence and survival during the last 2 decades. J Urol 164:1523–1525PubMed CrossRef
  2.Margulis V, Youssef RF, Karakiewicz PI, Lotan Y, Wood CG, Zigeuner R et al (2010) Preoperative multivariable prognostic model for prediction of nonorgan confined urothelial carcinoma of the upper urinary tract. J Urol 184:453–458PubMed CrossRef
  3.Lughezzani G, Burger M, Margulis V, Matin SF, Novara G, Roupret M et al (2012) Prognostic factors in upper urinary tract urothelial carcinomas: a comprehensive review of the current literature. Eur Urol 62:100–114PubMed CrossRef
  4.Favaretto RL, Shariat SF, Savage C, Godoy G, Chade DC, Kaag M et al (2012) Combining imaging and ureteroscopy variables in a preoperative multivariable model for prediction of muscle-invasive and non-organ confined disease in patients with upper tract urothelial carcinoma. BJU Int 109:77–82PubMed PubMedCentral CrossRef
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  7.Isbarn H, Jeldres C, Shariat SF, Liberman D, Sun M, Lughezzani G et al (2009) Location of the primary tumor is not an independent predictor of cancer specific mortality in patients with upper urinary tract urothelial carcinoma. J Urol 182:2177–2181PubMed CrossRef
  8.Raman JD, Ng CK, Scherr DS, Margulis V, Lotan Y, Bensalah K et al (2010) Impact of tumor location on prognosis for patients with upper tract urothelial carcinoma managed by radical nephroureterectomy. Eur Urol 57:1072–1079PubMed CrossRef
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  10.Ouzzane A, Colin P, Xylinas E, Pignot G, Ariane MM, Saint F et al (2011) Ureteral and multifocal tumours have worse prognosis than renal pelvic tumours in urothelial carcinoma of the upper urinary tract treated by nephroureterectomy. Eur Urol 60:1258–1265PubMed CrossRef
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• 作者单位：Laura-Maria Krabbe (1) (2)
  Aditya Bagrodia (1)
  Mary E. Westerman (1)
  Bishoy A. Gayed (1)
  Ahmed Q. Haddad (1)
  Arthur I. Sagalowsky (1)
  Shahrokh F. Shariat (1) (3)
  Payal Kapur (4)
  Yair Lotan (1)
  Vitaly Margulis (1)
  
  1. Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA
  2. Department of Urology, University of Muenster Medical Center, Albert-Schweitzer Campus 1, GB A1, 48149, Muenster, Germany
  3. Department of Urology, Vienna General Hospital, Medical University of Vienna, Vienna, Austria
  4. Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Urology and Andrology
  Nephrology
  Oncology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1433-8726

文摘

Purpose To assess the potential biologic impact of tumor location on oncological outcomes for patients with upper tract urothelial carcinoma (UTUC), we used prospectively collected molecular signatures of high-grade UTUC.