Exosomes derived from tumor cells genetically modified to express Mycobacterium tuberculosis antigen: a novel vaccine for cancer therapy

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• 作者：Yoshiyuki Koyama ; Tomoko Ito ; Aya Hasegawa ; Masazumi Eriguchi…
• 关键词：Cancer vaccine ; Early secretory antigenic target ; 6 (ESAT ; 6) ; Exogenous danger signal ; Exosomes ; Mycobacterium tuberculosis antigen ; Neoantigens ; Neoepitopes
• 刊名：Biotechnology Letters
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：38
• 期：11
• 页码：1857-1866
• 全文大小：1,364 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Microbiology
  Biotechnology
  Applied Microbiology
  Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-6776
• 卷排序：38

文摘

ObjectivesTo examine the potential of exosomes derived from the tumor cells, which had been genetically modified to express a Mycobacterium tuberculosis antigen, as a cancer vaccine aimed at overcoming the weak immunogenicity of tumor antigens.