Clinical value of ¹⁸F-fluorodihydroxyphenylalanine positron emission tomography/computed tomography (¹⁸F-DOPA PET/CT) for detecting pheochromocytoma

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• 作者：Markus Luster ; Wolfram Karges ; Katrin Zeich ; Sandra Pauls ; Frederik A. Verburg ; Henning Dralle ; Gerhard Glatting ; Andreas K. Buck ; Christoph Solbach and Bernd Neumaier ; et al.
• 关键词：Pheochromocytoma ; Multiple endocrine neoplasia type 2 (MEN2) ; 18F ; fluorodihydroxyphenylalanine (18F ; DOPA) ; Positron emission tomography (PET) ; Computed tomography (CT) ; Staging
• 刊名：European Journal of Nuclear Medicine and Molecular Imaging
• 出版年：2010
• 出版时间：March, 2010
• 年：2010
• 卷：37
• 期：3
• 页码：484-493
• 全文大小：726.5 KB

文摘

Purpose In detecting pheochromocytoma (PHEO), positron emission tomography (PET) with the radiolabelled amine precursor 18F-fluorodihydroxyphenylalanine (18F-DOPA) offers excellent specificity, while computed tomography (CT) provides high sensitivity and ability to localize lesions; therefore, the combination of these modalities could be advantageous in this setting. The aim of this study was to investigate whether combined 18F-DOPA PET/CT more accurately detects and localizes PHEO lesions than does each modality alone.