Imaging β-amyloid using [18F]flutemetamol positron emission tomography: from dosimetry to clinical diagnosis

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Imaging β-amyloid using [18F]flutemetamol positron emission tomography: from dosimetry to clinical diagnosis

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作者：Kerstin Heurling ; Antoine Leuzy…
关键词：β ; amyloid ; [18F]Flutemetamol ; Vizamyl ; Positron emission tomography ; Mild cognitive impairment ; Alzheimer’s disease
刊名：European Journal of Nuclear Medicine and Molecular Imaging
出版年：2016
出版时间：February 2016
年：2016
卷：43
期：2
页码：362-373
全文大小：944 KB
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作者单位：Kerstin Heurling (1)
Antoine Leuzy (2)
Eduardo R. Zimmer (3) (4)
Mark Lubberink (1)
Agneta Nordberg (2) (5)

1. Section of Nuclear Medicine and PET, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
2. Department NVS, Centre for Alzheimer Research, Division of Translational Alzheimer Neurobiology, Karolinska Institutet, Huddinge, Sweden
3. Brain Institute of Rio Grande do Sul (BraIns), Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil
4. Department of Biochemistry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil
5. Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
刊物类别：Medicine
刊物主题：Medicine & Public Health
Nuclear Medicine
Imaging and Radiology
Orthopedics
Cardiology
Oncology
出版者：Springer Berlin / Heidelberg
ISSN：1619-7089

文摘

In Alzheimer’s disease (AD), the deposition of β-amyloid (Aβ) is hypothesized to result in a series of secondary neurodegenerative processes, leading ultimately to synaptic dysfunction and neuronal loss. Since the advent of the first Aβ-specific positron emission tomography (PET) ligand, 11C-Pittsburgh compound B ([11C]PIB), several 18F ligands have been developed that circumvent the limitations of [11C]PIB tied to its short half-life. To date, three such compounds have been approved for clinical use by the US and European regulatory bodies, including [18F]AV-45 ([18F]florbetapir; Amyvid™), [18F]-BAY94-9172 ([18F]florbetaben; Neuraceq™) and [18F]3′-F-PIB ([18F]flutemetamol; Vizamyl™). The present review aims to summarize and discuss the currently available knowledge on [18F]flutemetamol PET. As the 18F analogue of [11C]PIB, [18F]flutemetamol may be of use in the differentiation of AD from related neurodegenerative disorders and may help with subject selection and measurement of target engagement in the context of clinical trials testing anti-amyloid therapeutics. We will also discuss its potential use in non-AD amyloidopathies.